PMID- 17119916
OWN - NLM
STAT- MEDLINE
DCOM- 20070926
LR  - 20181113
IS  - 0012-186X (Print)
IS  - 0012-186X (Linking)
VI  - 50
IP  - 2
DP  - 2007 Feb
TI  - Exercise under hyperinsulinaemic conditions increases whole-body glucose disposal 
      without affecting muscle glycogen utilisation in type 1 diabetes.
PG  - 414-21
AB  - AIMS/HYPOTHESIS: We examined whole-body and muscle metabolism in patients with 
      type 1 diabetes during moderate exercise at differing circulating insulin 
      concentrations. METHODS: Eight men (mean +/- SEM age 36.4 +/- 1.5 years; diabetes 
      duration 11.3 +/- 1.4 years; BMI 24.6 +/- 0.7 kg/m(2); HbA(1c) 7.9 +/- 0.2% and 
      VO(2) peak 44.5 +/- 1.2 ml kg(-1) min(-1)) with type 1 diabetes were studied on 
      two occasions at rest (2 h) and during 45 min of cycling at 60% maximum VO(2) 
      with insulin infused at the rate of either 15 (LO study) or 50 (HI) mU m(-2) 
      min(-1) and blood glucose clamped at 8 mmol/l. Indirect calorimetry, 
      insulin-glucose clamps and thigh muscle biopsies were employed to measure 
      whole-body energy and muscle metabolism. RESULTS: Fat oxidation contributed 15 
      and 23% to total energy expenditure during exercise in the HI and LO studies, 
      respectively. The respective carbohydrate (CHO) oxidation rates were 31.7 +/- 2.7 
      and 27.8 +/- 1.9 mg kg(-1) min(-1) (p < 0.05). Exogenous glucose utilisation rate 
      during exercise was substantially greater (p < 0.001) in the HI study (18.4 +/- 
      2.1 mg kg(-1) min(-1)) than in the LO study (6.9 +/- 1.2 mg kg(-1) min(-1)). 
      Muscle glycogen content fell by approximately 40% during exercise in both trials. 
      Muscle glycogen utilisation, muscle intermediary metabolism, and phosphorylation 
      of protein kinase B/Akt, glycogen synthase kinase 3alpha/beta and extracellular 
      signal-regulated protein kinase 1 and 2 proteins were no different between 
      interventions. CONCLUSIONS/INTERPRETATION: In patients with type 1 diabetes, 
      exercise under peak therapeutic insulin concentrations increases exogenous 
      glucose utilisation but does not spare muscle glycogen utilisation. A 
      disproportionate increase in exogenous glucose utilisation relative to the 
      increase in CHO oxidation suggests an increase in glucose flux through 
      non-oxidative pathways.
FAU - Chokkalingam, K
AU  - Chokkalingam K
AD  - Department of Diabetes and Endocrinology, Queen's Medical Centre, Nottingham, UK.
FAU - Tsintzas, K
AU  - Tsintzas K
FAU - Norton, L
AU  - Norton L
FAU - Jewell, K
AU  - Jewell K
FAU - Macdonald, I A
AU  - Macdonald IA
FAU - Mansell, P I
AU  - Mansell PI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061121
PL  - Germany
TA  - Diabetologia
JT  - Diabetologia
JID - 0006777
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 9005-79-2 (Glycogen)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 1/blood/*physiopathology
MH  - Energy Metabolism
MH  - Exercise/*physiology
MH  - Glucose/*metabolism
MH  - Glycogen/metabolism
MH  - Humans
MH  - Hyperinsulinism/*blood
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*physiopathology
MH  - Oxygen Consumption
EDAT- 2006/11/23 09:00
MHDA- 2007/09/27 09:00
CRDT- 2006/11/23 09:00
PHST- 2006/07/28 00:00 [received]
PHST- 2006/09/19 00:00 [accepted]
PHST- 2006/11/23 09:00 [pubmed]
PHST- 2007/09/27 09:00 [medline]
PHST- 2006/11/23 09:00 [entrez]
AID - 10.1007/s00125-006-0520-0 [doi]
PST - ppublish
SO  - Diabetologia. 2007 Feb;50(2):414-21. doi: 10.1007/s00125-006-0520-0. Epub 2006 
      Nov 21.