PMID- 17119951
OWN - NLM
STAT- MEDLINE
DCOM- 20070322
LR  - 20181113
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 59
IP  - 1
DP  - 2007 Jan
TI  - A modular concept of HLA for comprehensive peptide binding prediction.
PG  - 25-35
AB  - A variety of algorithms have been successful in predicting human leukocyte 
      antigen (HLA)-peptide binding for HLA variants for which plentiful experimental 
      binding data exist. Although predicting binding for only the most common HLA 
      variants may provide sufficient population coverage for vaccine design, 
      successful prediction for as many HLA variants as possible is necessary to 
      understand the immune response in transplantation and immunotherapy. However, the 
      high cost of obtaining peptide binding data limits the acquisition of binding 
      data. Therefore, a prediction algorithm, which applies the binding information 
      from well-studied HLA variants to HLA variants, for which no peptide data exist, 
      is necessary. To this end, a modular concept of class I HLA-peptide binding 
      prediction was developed. Accurate predictions were made for several alleles 
      without using experimental peptide binding data specific to those alleles. We 
      include a comparison of module-based prediction and supertype-based prediction. 
      The modular concept increased the number of predictable alleles from 15 to 75 of 
      HLA-A and 12 to 36 of HLA-B proteins. Under the modular concept, binding data of 
      certain HLA alleles can make prediction possible for numerous additional alleles. 
      We report here a ranking of HLA alleles, which have been identified to be the 
      most informative. Modular peptide binding prediction is freely available to 
      researchers on the web at http://www.peptidecheck.org .
FAU - DeLuca, David S
AU  - DeLuca DS
AD  - Institute for Transfusion Medicine, Hanover Medical School, Carl-Neuberg-Str 1, 
      30625 Hanover, Germany. blasczyk.rainer@mh-hannover.de
FAU - Khattab, Barbara
AU  - Khattab B
FAU - Blasczyk, Rainer
AU  - Blasczyk R
LA  - eng
PT  - Journal Article
DEP - 20061122
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA Antigens)
RN  - 0 (Peptide Library)
RN  - 0 (Peptides)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Combinatorial Chemistry Techniques/*methods
MH  - HLA Antigens/*chemistry/*genetics/immunology
MH  - Humans
MH  - Molecular Sequence Data
MH  - Peptide Library
MH  - Peptides/*chemistry/immunology
EDAT- 2006/11/23 09:00
MHDA- 2007/03/23 09:00
CRDT- 2006/11/23 09:00
PHST- 2006/07/14 00:00 [received]
PHST- 2006/10/25 00:00 [accepted]
PHST- 2006/11/23 09:00 [pubmed]
PHST- 2007/03/23 09:00 [medline]
PHST- 2006/11/23 09:00 [entrez]
AID - 10.1007/s00251-006-0176-4 [doi]
PST - ppublish
SO  - Immunogenetics. 2007 Jan;59(1):25-35. doi: 10.1007/s00251-006-0176-4. Epub 2006 
      Nov 22.