PMID- 17120741
OWN - NLM
STAT- MEDLINE
DCOM- 20080606
LR  - 20191110
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 26
IP  - 4
DP  - 2006
TI  - Naloxone or vagotomy does not influence centrally octreotide-induced inhibition 
      of gastric acid secretion in rats.
PG  - 432-5
AB  - To investigate the effect of preceding naloxone injection into the third 
      cerebroventricle or acute subdiaphragmatic vagotomy on the gastric acid secretion 
      inhibited by the somatostatin analogue octreotide given by 
      intracerebroventricular (icv) injection. The third ventricles were cannulated in 
      male Wistar rats anesthetized with sodium pentobarbital. One week later, acute 
      gastric lumen perfusion was carried out. The gastric perfusion samples were 
      collected every 10 min and were titrated by 0.01 mol/L NaOH to neuter. On the 
      basis of subcutaneous injection of pentagastrin (G-5, 160 micro, g/kg), icv 
      injection of physiological saline (group A, n = 20), icv injection of octreotide 
      (0.05 micro g) (group B, n = 20), icv injection of naloxone (2.5 micro 
      g)+octreotide (0.05 micro g) (group C, n = 20), acute subdiaphragmatic vagotomy+ 
      icv injection of physiological saline (group D, n = 20), or acute 
      subdiaphragmatic vagotomy+icv injection of octreotide (0.05 micro g) (group E, n 
      = 20) were conducted. Before and after icv injection, 1-h total acid output (TAO) 
      was determined and compared. The experimental data were expressed in change rate 
      (%) of TAO. The change rates (%) of TAO were 4.60% in group A, -20.35% in group 
      B, -18.06% in group C, 5.01% in group D and -21.59% in group E, respectively. 
      Comparison of group B or C versus group A showed that P < 0.01 and comparison 
      between the group E versus group D showed that P < 0.01. Whereas the differences 
      between group C and group B, group E and group B were not statistically 
      significant (P > 0.05 for all). The results indicate that the central inhibition 
      of gastric acid secretion by octreotide may not be mediated by the endogenous 
      opiate substance or its receptor and the peripheral pathway for icv injection of 
      octreotide to suppress gastric acid secretion is via extra-vagus route.
FAU - Gao, Feng
AU  - Gao F
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Hu, Xiufen
AU  - Hu X
FAU - Chen, Dongsheng
AU  - Chen D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Gastrointestinal Agents)
RN  - 36B82AMQ7N (Naloxone)
RN  - RWM8CCW8GP (Octreotide)
SB  - IM
MH  - Animals
MH  - Gastric Acid/*metabolism
MH  - Gastric Mucosa/metabolism
MH  - Gastrointestinal Agents/administration & dosage/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Naloxone/administration & dosage/*pharmacology
MH  - Octreotide/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Stomach/drug effects
MH  - *Vagotomy
EDAT- 2006/11/24 09:00
MHDA- 2008/06/07 09:00
CRDT- 2006/11/24 09:00
PHST- 2006/11/24 09:00 [pubmed]
PHST- 2008/06/07 09:00 [medline]
PHST- 2006/11/24 09:00 [entrez]
AID - 10.1007/s11596-006-0414-x [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2006;26(4):432-5. doi: 
      10.1007/s11596-006-0414-x.