PMID- 17121354
OWN - NLM
STAT- MEDLINE
DCOM- 20070330
LR  - 20131121
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 23
IP  - 5
DP  - 2006 Oct
TI  - [Preparation of graded zirconia-hydroxyapatite composite bioceramic and its 
      immunocompatibility in vitro].
PG  - 1056-61
AB  - Graded Zirconia-hydroxyapatite composite bioceramic and simplex 
      Zirconia-hydroxyapatite composite bioceramic were produced, and the extractes of 
      these two of materials were made to evaluate their immunocompatibility. Scanning 
      electron microscope (SEM) was used to detect the character of the surface of the 
      graded composite bioceramic. Holding and without holding phytohemagglutinin 
      (PHA), proliferation and activation of peripheralblood monocytes(PBMCs) cultured 
      in the two extracts were studied. Cultured in PHA after 72 hours, the 
      proliforation rate of the graded composite group was significantly higher than 
      the simplex composite group (P < 0.01). There was no difference of apoptosis of 
      PBMCs of the two groups (P > 0.05). Cultured in PHA after 24 hours, the ratio of 
      CD3/CD69 positive PBMCs of the simple composite group was significantly higher 
      than that of the graded composite material group (P < 0.01). The numbers of PBMCs 
      activated by the graded composite material group were less than that of the 
      simply composite material group and the technique of graded composite will be 
      helpful to improve its immunocompatibility.
FAU - Quan, Renfu
AU  - Quan R
AD  - Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University, 
      Hangzhou 310009, China. quanrenfu@126.com
FAU - Yang, Disheng
AU  - Yang D
FAU - Wu, Xiaochun
AU  - Wu X
FAU - Wang, Hongbin
AU  - Wang H
FAU - Miao, Xudong
AU  - Miao X
FAU - Li, Wei
AU  - Li W
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = 
      Shengwu yixue gongchengxue zazhi
JID - 9426398
RN  - 12001-21-7 (Dental Porcelain)
RN  - 91D9GV0Z28 (Durapatite)
RN  - C6V6S92N3C (Zirconium)
RN  - S38N85C5G0 (zirconium oxide)
SB  - IM
MH  - Adult
MH  - Cells, Cultured
MH  - *Dental Porcelain/chemistry/pharmacology
MH  - *Durapatite/chemistry/pharmacology
MH  - Humans
MH  - Materials Testing
MH  - Monocytes/*drug effects/immunology
MH  - *Zirconium/chemistry/pharmacology
EDAT- 2006/11/24 09:00
MHDA- 2007/03/31 09:00
CRDT- 2006/11/24 09:00
PHST- 2006/11/24 09:00 [pubmed]
PHST- 2007/03/31 09:00 [medline]
PHST- 2006/11/24 09:00 [entrez]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Oct;23(5):1056-61.