PMID- 17121586
OWN - NLM
STAT- MEDLINE
DCOM- 20070305
LR  - 20080528
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 17
IP  - 8
DP  - 2006 Dec
TI  - Influence of SNPs in cytokine-related genes on the severity of food allergy and 
      atopic eczema in children.
PG  - 583-90
AB  - Although many single nucleotide polymorphism (SNP) studies have reported an 
      association of atopy, allergic diseases and total serum immunoglobulin E (IgE) 
      levels, almost all of these studies sought risk factors for the onset of these 
      allergic diseases. Furthermore, many studies have analyzed a single gene and 
      hardly any have analyzed environmental factors. In these analyses, the results 
      could be masked and the effects of other genes and environmental factors may be 
      decreased. Here, we described the correlation between four genes [interleukin 
      (IL)-4 (C-590T), IL-4 receptor (A1652G), FCER1B (G6842A) and STAT6 (G2964A)] in 
      connection with IgE production; the role of IL-10 (C-627A) as a regulatory 
      cytokine of allergy; and the severity of food allergy (FA) and atopic eczema (AE) 
      in 220 Japanese allergic children. In addition to these SNPs, environmental 
      factors, i.e., patient's attitude, indoor environment, and so on, were also 
      investigated in this study. Our study was retrospective, and the correlation was 
      analyzed by our defined clinical scores divided into three terms: worst symptoms, 
      recent symptoms and general amelioration at the most recent examination during 
      the disease course. Our results indicated that IL-10 AA, the genotype with lower 
      IL-10 production, is associated with higher IgE levels in the serum (p < 0.0001, 
      estimate; 0.912). Marginal liver abnormalities were observed in the subject group 
      with both FA and AE (p < 0.1191, estimate; 0.1490). Our defined clinical scores 
      enabled evaluation of various aspects of disease severity. Based on the scores, 
      while no single SNP selected in this study determined severity, the combination 
      of the SNP with laboratory data and environmental factors appeared to determine 
      severity.
FAU - Negoro, Takaharu
AU  - Negoro T
AD  - Department of Medicinal Information, School of Pharmaceutical Sciences, Showa 
      University, Htanodai, Shinagawa-ku, Tokyo, Japan.
FAU - Orihara, Kanami
AU  - Orihara K
FAU - Irahara, Tomoko
AU  - Irahara T
FAU - Nishiyama, Hiroshi
AU  - Nishiyama H
FAU - Hagiwara, Kanae
AU  - Hagiwara K
FAU - Nishida, Risa
AU  - Nishida R
FAU - Takagi, Hiroki
AU  - Takagi H
FAU - Satoh, Kazue
AU  - Satoh K
FAU - Yamamoto, Yoshiki
AU  - Yamamoto Y
FAU - Shimizu, Shunichi
AU  - Shimizu S
FAU - Hagiwara, Tamio
AU  - Hagiwara T
FAU - Ishii, Masakazu
AU  - Ishii M
FAU - Tanioka, Toshihiro
AU  - Tanioka T
FAU - Nakano, Yasuko
AU  - Nakano Y
FAU - Takeda, Ken
AU  - Takeda K
FAU - Yoshimura, Isao
AU  - Yoshimura I
FAU - Iikura, Yoji
AU  - Iikura Y
FAU - Tobe, Takashi
AU  - Tobe T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Cytokines)
RN  - 0 (Receptors, IgE)
RN  - 0 (Receptors, Interleukin-4)
RN  - 0 (STAT6 Transcription Factor)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Air Pollution, Indoor
MH  - Attitude
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*genetics
MH  - Dermatitis, Atopic/epidemiology/etiology/*genetics
MH  - Food Hypersensitivity/epidemiology/etiology/*genetics
MH  - Humans
MH  - Immunoglobulin E/biosynthesis
MH  - Interleukin-10/physiology
MH  - Interleukin-4/genetics
MH  - Liver Diseases/etiology
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, IgE/genetics
MH  - Receptors, Interleukin-4/genetics
MH  - Retrospective Studies
MH  - Risk Factors
MH  - STAT6 Transcription Factor/genetics
MH  - *Severity of Illness Index
EDAT- 2006/11/24 09:00
MHDA- 2007/03/06 09:00
CRDT- 2006/11/24 09:00
PHST- 2006/11/24 09:00 [pubmed]
PHST- 2007/03/06 09:00 [medline]
PHST- 2006/11/24 09:00 [entrez]
AID - PAI463 [pii]
AID - 10.1111/j.1399-3038.2006.00463.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2006 Dec;17(8):583-90. doi: 
      10.1111/j.1399-3038.2006.00463.x.