PMID- 17121587
OWN - NLM
STAT- MEDLINE
DCOM- 20070305
LR  - 20131121
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 17
IP  - 8
DP  - 2006 Dec
TI  - Patterns of sensitization in infants and its relation to atopic dermatitis.
PG  - 591-600
AB  - Longitudinal studies in infant populations using validated diagnostic criteria of 
      atopic dermatitis and sensitization are rarely reported, and disease definitions, 
      testing procedures, age of study population and evaluation of objective markers 
      vary between countries and studies. The objectives of this prospective birth 
      cohort study were to investigate: (i) the prevalence, the cumulative incidence 
      and the pattern of transient and persistent sensitization to common food- and 
      aeroallergens in unselected infants, (ii) the association between sensitization 
      and the development of atopic dermatitis (AD) and (iii) the association between 
      selected perinatal risk factors with respect to AD and post-natal sensitization. 
      During a one-year period a cohort of 562 unselected newborns was established and 
      followed up at the age of 3, 6, 9, 12 and 18 months of age. At all time points 
      infants were examined clinically and by histamine release (HR), total- and 
      specific immunoglobulin E (IgE) and skin prick test (SPT). Sensitization ever to 
      > or =1 allergen at 18 months of age was 59%, 50% and 6% using HR, IgE and SPT, 
      respectively. A transient sensitization to > or =1 allergen was found in 47%, 42% 
      and 4% and a persistent sensitization in 17%, 10% and 3%, respectively. 
      Sensitization to environmental allergens was frequently observed in infancy when 
      testing with HR and IgE. Results of SPT gave much lower frequencies. Reactivity 
      to foods was more frequent than to aeroallergens. The dominant pattern was 
      low-level transient sensitization. This is important to know when sensitization 
      tests are used in the course of examination of infants with eczematous skin 
      diseases. Specific definitions of sensitization like persistent reactivity, 
      high-level sensitization and poly sensitization were clearly associated with AD. 
      A maternal history of AD was a valuable tool in predicting AD in early infancy; a 
      similar finding was less obvious with regard to post-natal sensitization. 
      Cord-specific IgE and cord-HR positive reactivity did not prove better tools than 
      cord-total IgE in predicting AD within the first 18 living months.
FAU - Johnke, Hanne
AU  - Johnke H
AD  - Department of Dermato-venereology, University of Southern Denmark, Odense, 
      Denmark. hj@dadlnet.dk
FAU - Norberg, Lene Annette
AU  - Norberg LA
FAU - Vach, Werner
AU  - Vach W
FAU - Host, Arne
AU  - Host A
FAU - Andersen, Klaus Ejner
AU  - Andersen KE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Cohort Studies
MH  - Dermatitis, Atopic/diagnosis/epidemiology/*etiology
MH  - Food Hypersensitivity
MH  - Histamine/analysis
MH  - Humans
MH  - Hypersensitivity/*complications/diagnosis/epidemiology
MH  - Immunoglobulin E/analysis
MH  - Infant
MH  - Longitudinal Studies
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
MH  - Skin Tests
EDAT- 2006/11/24 09:00
MHDA- 2007/03/06 09:00
CRDT- 2006/11/24 09:00
PHST- 2006/11/24 09:00 [pubmed]
PHST- 2007/03/06 09:00 [medline]
PHST- 2006/11/24 09:00 [entrez]
AID - PAI453 [pii]
AID - 10.1111/j.1399-3038.2006.00453.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2006 Dec;17(8):591-600. doi: 
      10.1111/j.1399-3038.2006.00453.x.