PMID- 17121589
OWN - NLM
STAT- MEDLINE
DCOM- 20070305
LR  - 20080528
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 17
IP  - 8
DP  - 2006 Dec
TI  - Sublingual desensitization in children with congenital malformations and latex 
      allergy.
PG  - 606-12
AB  - The frequency of latex allergy in children requiring multiple surgery ranges from 
      16.7% to 65%. The aim of this study was to investigate the safety and efficacy of 
      latex desensitization in a group of 10 patients with a history of multiple 
      surgical procedures and clinically manifested allergy to latex. We selected 10 
      children (female-male ratio = 5:5), aged 4-16 yr (mean +/- s.d.: 9 +/- 4), with a 
      history of multiple surgical procedures, adverse reactions to latex and positive 
      skin test to latex and/or specific immunoglobulin E (IgE). Latex allergy 
      diagnosis was confirmed by specific provocation tests (cutaneous, sublingual, 
      mucous, conjunctival tests). Rush (4-day) sublingual desensitization was 
      performed with increasing doses of latex extract (ALK Abello) under patients' 
      tongue until the highest dose of 500 microg of latex. A maintenance therapy (10 
      drops of undiluted solution three times a week) was recommended. During the 2-yr 
      follow-up mean values of specific IgG4 and IgE, eosinophilic cationic protein and 
      total IgE did not show significant variations. Patients did not manifest any 
      adverse effect during the rush phase and only two patients manifested mild local 
      symptoms during the maintenance therapy. All the challenges showed a reduction in 
      terms of percentage of positivity and mean scores. All the patients showed a 
      reduction of the mean individual score (p < 0.001). Furthermore patients who 
      needed dental examination or surgery underwent such procedures without the 
      occurrence of symptoms. Our preliminary results show sublingual desensitization 
      to latex can be an important therapeutic tool in the management of young allergic 
      patients requiring multiple operations.
FAU - Nucera, E
AU  - Nucera E
AD  - Department of Allergology, Universita Catholica Del Sacro Cuore, Policlinico, A. 
      Germelli, Rome, Italy.
FAU - Schiavino, D
AU  - Schiavino D
FAU - Pollastrini, E
AU  - Pollastrini E
FAU - Rendeli, C
AU  - Rendeli C
FAU - Pietrini, D
AU  - Pietrini D
FAU - Tabacco, F
AU  - Tabacco F
FAU - De Pasquale, T
AU  - De Pasquale T
FAU - Ausili, E
AU  - Ausili E
FAU - Sabato, V
AU  - Sabato V
FAU - Roncallo, C
AU  - Roncallo C
FAU - Patriarca, G
AU  - Patriarca G
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Immunoglobulin G)
RN  - 0 (Latex)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
SB  - IM
MH  - Administration, Sublingual
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Congenital Abnormalities/surgery
MH  - Eosinophil Cationic Protein/analysis
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Immunoglobulin G/analysis
MH  - Latex/*administration & dosage/adverse effects/immunology
MH  - Latex Hypersensitivity/*therapy
MH  - Male
MH  - Perioperative Care
MH  - *Surgical Procedures, Operative
EDAT- 2006/11/24 09:00
MHDA- 2007/03/06 09:00
CRDT- 2006/11/24 09:00
PHST- 2006/11/24 09:00 [pubmed]
PHST- 2007/03/06 09:00 [medline]
PHST- 2006/11/24 09:00 [entrez]
AID - PAI458 [pii]
AID - 10.1111/j.1399-3038.2006.00458.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2006 Dec;17(8):606-12. doi: 
      10.1111/j.1399-3038.2006.00458.x.