PMID- 17122510
OWN - NLM
STAT- MEDLINE
DCOM- 20070104
LR  - 20171116
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 30
IP  - 12
DP  - 2006 Dec
TI  - The incidence and anatomic site specificity of chromosomal translocations in 
      primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid 
      tissue (MALT lymphoma) in North America.
PG  - 1546-53
AB  - Several balanced translocations have been identified in extranodal marginal zone 
      B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) but there 
      are few data regarding their frequency in different anatomic sites or the 
      frequency of translocations involving BCL6 or kappa or lambda immunoglobulin 
      light chain genes (IGK or IGL), particularly in patients from geographic regions 
      other than Europe and Japan. One hundred thirty-three paraffin-embedded North 
      American primary MALT lymphoma specimens from diverse anatomic sites were studied 
      by fluorescence in situ hybridization (FISH) using probes for API2-MALT1, 
      IGH-MALT1, IGH-BCL10, IGH-FOXP1, IGH, +/- centromeres 3, 7, 12, and 18, and a 
      subset (n=74) were analyzed using FISH probes for IGK, IGL, and BCL6. 
      Translocations were mutually exclusive and were detected in 26% of cases (17% 
      API2-MALT1, 5% IGH-MALT1, 3% IGH-unknown translocation partner, and 1% 
      IGH-BCL10). Aneuploidy was associated with IGH-MALT1 and IGH-BCL10 but only 
      rarely with API2-MALT1. There was striking site specificity, with API2-MALT1 
      showing a marked predilection for lung and intestine, and IGH-MALT1 and IGH-BCL10 
      occurring almost exclusively in lung. Twenty-three percent of 
      translocation-negative primary MALT lymphomas from diverse sites showed 
      complete/partial trisomy 18. No MALT lymphomas with translocations involving IGK, 
      IGL, BCL6, or FOXP1 were identified. This FISH panel detected cytogenetic 
      abnormalities in half of all MALT lymphomas, and translocations arose 
      preferentially in MALT lymphomas of the lung and gastrointestinal tract. 
      Differences in incidence and anatomic site specificity of translocations between 
      North American and non-North American cases may reflect geographic variability of 
      infectious or other etiologic factors.
FAU - Remstein, Ellen D
AU  - Remstein ED
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester MN 55905, 
      USA. remstein.ellen@mayo.edu
FAU - Dogan, Ahmet
AU  - Dogan A
FAU - Einerson, Richard R
AU  - Einerson RR
FAU - Paternoster, Sarah F
AU  - Paternoster SF
FAU - Fink, Stephanie R
AU  - Fink SR
FAU - Law, Mark
AU  - Law M
FAU - Dewald, Gordon W
AU  - Dewald GW
FAU - Kurtin, Paul J
AU  - Kurtin PJ
LA  - eng
GR  - CA97274/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (API2-MALT1 fusion protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (B-Cell CLL-Lymphoma 10 Protein)
RN  - 0 (BCL10 protein, human)
RN  - 0 (Genetic Markers)
RN  - 0 (Immunoglobulin Light Chains)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (MALT1 protein, human)
RN  - EC 3.4.22.- (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/genetics/metabolism
MH  - *Aneuploidy
MH  - B-Cell CLL-Lymphoma 10 Protein
MH  - Caspases/genetics
MH  - Genetic Markers/genetics
MH  - Humans
MH  - Immunoglobulin Light Chains/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Incidence
MH  - Intestinal Neoplasms/*genetics/pathology
MH  - Lung Neoplasms/*genetics/pathology
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics/immunology/pathology
MH  - Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
MH  - Neoplasm Proteins/genetics
MH  - North America
MH  - Oncogene Proteins, Fusion/genetics/metabolism
MH  - Organ Specificity
MH  - Tissue Array Analysis
MH  - Translocation, Genetic/*genetics
EDAT- 2006/11/24 09:00
MHDA- 2007/01/05 09:00
CRDT- 2006/11/24 09:00
PHST- 2006/11/24 09:00 [pubmed]
PHST- 2007/01/05 09:00 [medline]
PHST- 2006/11/24 09:00 [entrez]
AID - 00000478-200612000-00007 [pii]
AID - 10.1097/01.pas.0000213275.60962.2a [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2006 Dec;30(12):1546-53. doi: 
      10.1097/01.pas.0000213275.60962.2a.