PMID- 1712273
OWN - NLM
STAT- MEDLINE
DCOM- 19910815
LR  - 20181113
IS  - 0012-6667 (Print)
IS  - 0012-6667 (Linking)
VI  - 41 Suppl 1
DP  - 1991
TI  - Cilazapril in congestive heart failure. A pilot study.
PG  - 54-61
AB  - The haemodynamic effects of a single dose of cilazapril 2.5 or 5 mg were studied 
      in 33 patients with stable chronic congestive heart failure who were receiving 
      digitalis and diuretics. Subsequently, a double-blind comparison of the 
      haemodynamic and clinical effects of 3 months' treatment with cilazapril 1.25 to 
      5 mg daily or placebo in 24 evaluable patients revealed that the acute 
      haemodynamic improvement produced by a single dose of cilazapril was maintained 
      in patients receiving repeated administration of the drug, but not in those 
      randomly allocated the placebo. Acute cilazapril significantly decreased mean 
      arterial pressure, systemic vascular resistance, pulmonary capillary wedge 
      pressure, pulmonary artery pressure and right atrial pressure, while cardiac 
      index and stroke volume index increased at rest and during submaximal exercise. 
      After 3 months' treatment 11 of 13 cilazapril recipients improved their New York 
      Heart Association (NYHA) class compared with 2 of 11 patients treated with 
      placebo. This functional improvement was paralleled by a patient-perceived 
      improvement in general well-being.
FAU - Kiowski, W
AU  - Kiowski W
AD  - Division of Cardiology, University Hospital, Basel, Switzerland.
FAU - Drexler, H
AU  - Drexler H
FAU - Meinertz, T
AU  - Meinertz T
FAU - Zuber, M
AU  - Zuber M
FAU - Ritz, R
AU  - Ritz R
FAU - Burkart, F
AU  - Burkart F
FAU - Just, H
AU  - Just H
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - New Zealand
TA  - Drugs
JT  - Drugs
JID - 7600076
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Pyridazines)
RN  - 19KW7PI29F (Cilazapril)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
MH  - Cilazapril
MH  - Drug Administration Schedule
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/*drug therapy
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Pyridazines/*therapeutic use
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.2165/00003495-199100411-00010 [doi]
PST - ppublish
SO  - Drugs. 1991;41 Suppl 1:54-61. doi: 10.2165/00003495-199100411-00010.