PMID- 17123719
OWN - NLM
STAT- MEDLINE
DCOM- 20070330
LR  - 20131121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 411
IP  - 3
DP  - 2007 Jan 16
TI  - Distribution of Notch1-expressing cells and proliferating cells in mouse 
      vomeronasal organ.
PG  - 217-21
AB  - Vomeronasal receptor neurons (VRNs) proliferate and differentiate continuously in 
      the vomeronasal organ (VNO) throughout life. In adult mice, new VRNs are 
      generated mainly in the marginal region, located in the boundary region between 
      sensory and nonsensory epithelia. The Notch signaling pathway is involved in 
      differentiation in the developing nervous system. To understand the Notch 
      signaling pathway involved in generating VRNs, we focused on the relationship 
      between the expression pattern of Notch1 and the localization of proliferating 
      cells in both developing and regenerating mice VNO, and examined the Notch 
      signaling pathway involved in the development of VNO by in situ hybridization of 
      Notch1 and immunocytochemistry of 5-bromo-2'-deoxyuridine. During embryonic and 
      neonatal development, proliferating cells and Notch1-expressing (+) cells were 
      observed evenly throughout VNO. A large number of proliferating cells and Notch1 
      (+) cells were observed in embryonic VNO, but gradually decreased during 
      development. The localization of proliferating cells was similar to that of 
      Notch1 (+) cells at each developmental stage. In adult VNO, there are a few 
      proliferating cells and Notch1 (+) cells, which were only in the marginal region 
      of VNO. Seven days after removal of the accessory olfactory bulb (AOB), VRNs 
      proliferated throughout VNO. Although the number of Notch1 (+) cells also 
      increased in VNO, the majority of these were concentrated in the dorsal region of 
      VNO, suggesting that it has two types of differentiating cell. These results 
      suggest that Notch1 plays a role in the differentiation of VRNs during 
      development and regeneration of VRNs after removal of AOB.
FAU - Wakabayashi, Yoshihiro
AU  - Wakabayashi Y
AD  - Laboratory of Anatomy and Cell Biology, Department of Neuroscience Basic 
      Technology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 
      Tokyo 183-8526, Japan. ywaka@tmin.ac.jp
FAU - Ichikawa, Masumi
AU  - Ichikawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061122
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Notch1 protein, mouse)
RN  - 0 (Receptor, Notch1)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Bromodeoxyuridine/metabolism
MH  - *Cell Proliferation
MH  - Embryo, Mammalian
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Mice
MH  - Neurons/*cytology/metabolism/physiology
MH  - Receptor, Notch1/genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - Vomeronasal Organ/*cytology/embryology/growth & development
EDAT- 2006/11/25 09:00
MHDA- 2007/03/31 09:00
CRDT- 2006/11/25 09:00
PHST- 2006/06/24 00:00 [received]
PHST- 2006/09/12 00:00 [revised]
PHST- 2006/09/15 00:00 [accepted]
PHST- 2006/11/25 09:00 [pubmed]
PHST- 2007/03/31 09:00 [medline]
PHST- 2006/11/25 09:00 [entrez]
AID - S0304-3940(06)00994-3 [pii]
AID - 10.1016/j.neulet.2006.09.088 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Jan 16;411(3):217-21. doi: 10.1016/j.neulet.2006.09.088. Epub 
      2006 Nov 22.