PMID- 17123918
OWN - NLM
STAT- MEDLINE
DCOM- 20071120
LR  - 20191110
IS  - 0265-2048 (Print)
IS  - 0265-2048 (Linking)
VI  - 23
IP  - 7
DP  - 2006 Nov
TI  - Controlled delivery of a hydrophilic drug from a biodegradable microsphere system 
      by supercritical anti-solvent precipitation technique.
PG  - 741-9
AB  - The purpose of this study was to prepare microspheres loaded with hydrophilic 
      drug, bupivacaine HCl using poly(D,L-lactic-co-glycolic acid) (PLGA) and 
      poly(L-lactic acid) (PLLA). Microspheres were prepared with varying the PLGA/PLLA 
      ratio with two different levels of bupivacaine HCl (5 and 10%) using a 
      supercritical anti-solvent (SAS) technique. Microspheres ranging from 4-10 microm 
      in geometric mean diameter could be prepared, with high loading efficiency. 
      Powder X-ray diffraction (PXRD) revealed that bupivacaine HCl retained its 
      crystalline state within the polymer and was present as a dispersion within the 
      polymer phase after SAS processing. The release of bupivacaine HCl from 
      biodegradable polymer microspheres was rapid up to 4 h, thereafter bupivacaine 
      HCl was continuously and slowly released for at least 7 days according to the 
      PLGA/PLLA ratio and the molecular weight of PLLA.
FAU - Lee, S
AU  - Lee S
AD  - National Research Lab of Pharmaceutical Technology, College of Pharmacy, Chungnam 
      National University, Daejeon, Korea.
FAU - Kim, M S
AU  - Kim MS
FAU - Kim, J S
AU  - Kim JS
FAU - Park, H J
AU  - Park HJ
FAU - Woo, J S
AU  - Woo JS
FAU - Lee, B C
AU  - Lee BC
FAU - Hwang, S J
AU  - Hwang SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Microencapsul
JT  - Journal of microencapsulation
JID - 8500513
RN  - 0 (Biocompatible Materials)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 0 (Solvents)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 459TN2L5F5 (poly(lactide))
RN  - QTT17582CB (Hydrochloric Acid)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Absorbable Implants
MH  - Biocompatible Materials/chemistry
MH  - Bupivacaine/*administration & dosage
MH  - Chemical Precipitation
MH  - Delayed-Action Preparations/administration & dosage
MH  - Drug Compounding/methods
MH  - Hydrochloric Acid/chemistry
MH  - Lactic Acid/chemistry
MH  - Microscopy, Electron, Scanning
MH  - *Microspheres
MH  - Particle Size
MH  - Polyesters
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/chemistry
MH  - Solvents/chemistry
MH  - Surface Properties
MH  - X-Ray Diffraction
EDAT- 2006/11/25 09:00
MHDA- 2007/12/06 09:00
CRDT- 2006/11/25 09:00
PHST- 2006/11/25 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2006/11/25 09:00 [entrez]
AID - J21511371217137N [pii]
AID - 10.1080/09687860600945552 [doi]
PST - ppublish
SO  - J Microencapsul. 2006 Nov;23(7):741-9. doi: 10.1080/09687860600945552.