PMID- 17125042
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20161020
IS  - 1122-0643 (Print)
IS  - 1122-0643 (Linking)
VI  - 66
IP  - 1
DP  - 2006 Mar
TI  - [Acute myocardial infarction in the elderly. A case-control study with a younger 
      population and review of literature].
PG  - 13-9
AB  - BACKGROUND: ST elevation myocardial infarction (STEMI) in old and old-old 
      patients presents several peculiarities in natural history, delay of 
      hospitalization and response to treatment. Aim of this retrospective case control 
      study was to determine presentation, complications and management of elderly 
      patients with STEMI compared to a younger population. METHODS: 462 patients (205 
      M and 257 F) aged > or =75 years, hospitalized in CCU between 1999 and 2003 for 
      STEMI, were evaluated. The control group consisted of 490 consecutive patients 
      (268 M and 222 F) aged 50-70 years. Attention was focused on clinical 
      presentation, complications, management and outcome in elderly compared with 
      younger patients. RESULTS: The mean interval between the onset of symptoms and 
      the arrive in CCU was of 9 hour in the elderly compared to 4,5 hour in the 
      control. Chest pain was less frequent (50% vs 90%) in the elderly; the prevalence 
      of dyspnoea and neurological symptoms was higher in patients >75 years (30% vs. 
      15% and 25% vs. 10%). In the elderly, previous angina and AMI, cerebral and 
      peripheral vascular diseases, peripheral and renal failure were frequent. Early 
      severe complications prevailed in the elderly. Thrombolysis was performed only in 
      39% of the elderly compared to 65% of the control. Significantly higher was 
      cerebral haemorrhage after thrombolysis (4.9% vs. 1.8%). Comparable were the 
      mayor extra cranial bleedings. Primary or facilitated PTCA was performed in few 
      patients in the last year. Two weeks mortality was 20%, compared to 6.5% in the 
      control group. CONCLUSION: The patients >75 years with STEMI were hospitalized 
      later, had atypical presentation with less chest pain and more cardiac failure, 
      were less likely to receive thrombolysis, had more complications and more 
      cerebral bleedings. Elderly had more associated diseases and in-hospital 
      mortality was higher.
FAU - Corsini, Fabrizio
AU  - Corsini F
AD  - IV Divisione di Medicina Interna, Seconda Universita degli Studi di Napoli. 
      fabrizio.corsini@libero.it
FAU - Scaglione, Anna
AU  - Scaglione A
FAU - Iacomino, Maria
AU  - Iacomino M
FAU - Mascia, Giuseppe
AU  - Mascia G
FAU - Melorio, Saverio
AU  - Melorio S
FAU - Riccio, Carmine
AU  - Riccio C
FAU - Romano, Salvatore
AU  - Romano S
FAU - Vetrano, Alfredo
AU  - Vetrano A
FAU - Celardo, Silvana
AU  - Celardo S
FAU - Corsini, Giancarlo
AU  - Corsini G
FAU - Chieffo, Carmelo
AU  - Chieffo C
LA  - ita
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
PT  - Review
TT  - L'infarto miocardico acuto nell'ultrasettantacinquenne. Studio caso-controllo con 
      una popolazione piu giovane e rassegna della letteratura.
PL  - Italy
TA  - Monaldi Arch Chest Dis
JT  - Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
JID - 9307314
RN  - 0 (Fibrinolytic Agents)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging
MH  - Angioplasty, Balloon, Coronary
MH  - Case-Control Studies
MH  - Electrocardiography
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Fibrinolytic Agents/adverse effects/therapeutic use
MH  - Heart Conduction System/*physiopathology
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*diagnosis/mortality/physiopathology/therapy
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Analysis
RF  - 41
EDAT- 2006/11/28 09:00
MHDA- 2007/01/17 09:00
CRDT- 2006/11/28 09:00
PHST- 2006/11/28 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2006/11/28 09:00 [entrez]
AID - 10.4081/monaldi.2006.537 [doi]
PST - ppublish
SO  - Monaldi Arch Chest Dis. 2006 Mar;66(1):13-9. doi: 10.4081/monaldi.2006.537.