PMID- 17125926
OWN - NLM
STAT- MEDLINE
DCOM- 20070405
LR  - 20161124
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 413
IP  - 1
DP  - 2007 Feb 8
TI  - Sex steroids modulate the signals from volatile female odors in the accessory 
      olfactory bulb of male mice.
PG  - 11-5
AB  - We previously reported that male mice detect volatile female odors via the 
      accessory olfactory system, and that these odors activate granule cells in the 
      accessory olfactory bulb (AOB) with a characteristic pattern. We also reported 
      that sex steroids modulate the attraction of male mice to volatile female odors. 
      The present study investigated hormonal modulation of signals from volatile 
      female odors in the AOB with c-Fos immunostaining. After intact male mice were 
      exposed to volatile female odors, there were more c-Fos positive cells in the 
      caudal granule cell layer (GCL) than in the rostral GCL of the AOB. This effect 
      was observed 3 days but not 7 days after castration, suggesting that hormonal 
      deficiency causes the reorganization of the AOB after 3 days. There was no 
      difference in the number of c-Fos positive cells between the rostral and caudal 
      GCL of castrated male mice treated with 17 beta-estradiol (E). In contrast, there 
      were more c-Fos positive cells in the caudal GCL than in the rostral GCL of 
      castrated male mice treated with dihydrotestosterone (DHT). In both DHT- and 
      E-treated castrated male mice, there was no difference in the number of c-Fos 
      positive cells between the rostral GCL and caudal GCL. This finding suggests that 
      E disrupts the effect of DHT, and that androgen is required for maintaining the 
      intact neuronal network of the AOB. The present study suggests that sex steroids 
      modulate the signals from volatile female odors in the AOB of male mice.
FAU - Yoshikage, Muroi
AU  - Yoshikage M
AD  - Department of Pathogenetic Veterinary Science, The United Graduate School of 
      Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
FAU - Toshiaki, Ishii
AU  - Toshiaki I
FAU - Seiichi, Komori
AU  - Seiichi K
FAU - Nobuo, Kitamura
AU  - Nobuo K
FAU - Nishimura, Masakazu
AU  - Nishimura M
LA  - eng
PT  - Journal Article
DEP - 20061127
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Androgens)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 08J2K08A3Y (Dihydrotestosterone)
SB  - IM
MH  - Androgens/*pharmacology
MH  - Animals
MH  - Dihydrotestosterone/*pharmacology
MH  - Female
MH  - Immunohistochemistry/methods
MH  - Male
MH  - Mice
MH  - Neurons/*drug effects/metabolism
MH  - *Odorants
MH  - Olfactory Bulb/cytology/*drug effects/physiology
MH  - Orchiectomy/methods
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Smell/*drug effects
MH  - Time Factors
EDAT- 2006/11/28 09:00
MHDA- 2007/04/06 09:00
CRDT- 2006/11/28 09:00
PHST- 2006/09/01 00:00 [received]
PHST- 2006/11/09 00:00 [revised]
PHST- 2006/11/11 00:00 [accepted]
PHST- 2006/11/28 09:00 [pubmed]
PHST- 2007/04/06 09:00 [medline]
PHST- 2006/11/28 09:00 [entrez]
AID - S0304-3940(06)01227-4 [pii]
AID - 10.1016/j.neulet.2006.11.025 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Feb 8;413(1):11-5. doi: 10.1016/j.neulet.2006.11.025. Epub 
      2006 Nov 27.