PMID- 17126336
OWN - NLM
STAT- MEDLINE
DCOM- 20070228
LR  - 20091119
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 87
IP  - 2
DP  - 2007 Feb
TI  - Sperm chromosome analysis in two cases of paracentric inversion.
PG  - 418.e1-5
AB  - OBJECTIVE: To examine sperm meiotic segregation in men with paracentric 
      inversions. DESIGN: Cases reports, literature review. SETTING: Departments of 
      reproductive biology, cytogenetics, gynaecology, and obstetrics. PATIENT(S): Two 
      patients referred for infertility, heterozygous for a paracentric inversion. 
      INTERVENTION(S): Fluorescence in situ hybridization (FISH) with specific probes 
      and X/Y/18 centromeric probes on 1,000 spermatozoa for the 2 patients and 10 
      controls. MAIN OUTCOME MEASURE(S): Sperm aneuploidy frequency. RESULT(S): The 
      FISH analysis using the specific probes for the paracentric inversion indicated 
      low disequilibrium (0.4% and 0.5%). The FISH analysis using X/Y/18 centromeric 
      probes indicated aneuploidy frequencies (0.3% and 1.1%), identical to those of 
      control patients with the same sperm parameters. CONCLUSION(S): Paracentric 
      inversion seems to be associated with a very low risk of aneuploidy. A larger 
      study is necessary to explore all chromosome inversions.
FAU - Vialard, Francois
AU  - Vialard F
AD  - Departments of reproductive biology, cytogenetics, gynaecology and obstetrics, 
      CHIPS, Poissy, France; INSERM U407, Oullins, France. fvialard@hotmail.com 
      <fvialard@hotmail.com>
FAU - Delanete, Audoin
AU  - Delanete A
FAU - Clement, Patrice
AU  - Clement P
FAU - Simon-Bouy, Brigitte
AU  - Simon-Bouy B
FAU - Aubriot, Francois Xavier
AU  - Aubriot FX
FAU - Selva, Jacqueline
AU  - Selva J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20061127
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adult
MH  - Chromosome Inversion/*genetics
MH  - Chromosomes, Human, X/*genetics
MH  - Chromosomes, Human, Y/*genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Humans
MH  - Infertility, Male/*genetics
MH  - Male
MH  - *Sex Chromosome Aberrations
MH  - Spermatozoa/*abnormalities/*ultrastructure
EDAT- 2006/11/28 09:00
MHDA- 2007/03/01 09:00
CRDT- 2006/11/28 09:00
PHST- 2006/02/07 00:00 [received]
PHST- 2006/05/11 00:00 [revised]
PHST- 2006/05/11 00:00 [accepted]
PHST- 2006/11/28 09:00 [pubmed]
PHST- 2007/03/01 09:00 [medline]
PHST- 2006/11/28 09:00 [entrez]
AID - S0015-0282(06)03863-5 [pii]
AID - 10.1016/j.fertnstert.2006.05.087 [doi]
PST - ppublish
SO  - Fertil Steril. 2007 Feb;87(2):418.e1-5. doi: 10.1016/j.fertnstert.2006.05.087. 
      Epub 2006 Nov 27.