PMID- 17127799
OWN - NLM
STAT- MEDLINE
DCOM- 20070124
LR  - 20220310
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 70
IP  - 12
DP  - 2006 Dec
TI  - Association of hyperadiponectinemia with severity of ventricular dysfunction in 
      congestive heart failure.
PG  - 1557-62
AB  - BACKGROUND: Adiponectin, which is a collagen-like plasma protein produced by 
      adipose tissue, has anti-atherogenic and anti-inflammatory effects. Plasma 
      adiponectin levels in patients with congestive heart failure (CHF) were 
      determined, as well as relationships between the plasma levels of adiponectin and 
      other hormones. METHODS AND RESULTS: The study group comprised 90 patients with 
      CHF and 20 control subjects, who were divided into 4 subgroups according to New 
      York Heart Association (NYHA) functional class. Plasma levels of adiponectin, 
      tumor necrosis factor (TNF)-alpha and brain natriuretic peptide (BNP) and cardiac 
      hemodynamics were determined. Plasma adiponectin levels were significantly 
      increased according to the severity of NYHA class in the patients with CHF; 
      control: 6.2+/-1.0; NYHA I: 8.5+/-1.9, NYHA II: 12.0+/-2.2, NYHA III: 13.0+/-2.7, 
      NYHA IV: 14.9+/-2.7 microg/ml (p=0.0008). Similarly, plasma BNP levels were 
      significantly increased in accordance with the NYHA class. Plasma adiponectin 
      levels correlated positively with BNP (r=0.40, p=0.0002) and TNF-alpha (r=0.49, 
      p=0.0001), and correlated negatively with cardiac index (r=-0.27, p=0.05). In 24 
      of 46 patients in the NYHA III and IV subgroups, according to the prompt 
      improvement in cardiac function, levels of both plasma adiponectin and BNP were 
      significantly reduced (p<0.0001). CONCLUSION: Plasma adiponectin levels increased 
      according to the severity of CHF and, moreover, they correlated with the plasma 
      levels of BNP and TNF-alpha. These results indicate that augmented release of 
      adiponectin is involved in the pathogenesis of CHF and further study is needed to 
      elucidate its exact role.
FAU - Nakamura, Tomohiro
AU  - Nakamura T
AD  - Department of Medicine, Jichi Medical University Omiya Medical Center, Saitama. 
      Japan.
FAU - Funayama, Hiroshi
AU  - Funayama H
FAU - Kubo, Norifumi
AU  - Kubo N
FAU - Yasu, Takanori
AU  - Yasu T
FAU - Kawakami, Masanobu
AU  - Kawakami M
FAU - Saito, Muneyasu
AU  - Saito M
FAU - Momomura, Shin-ichi
AU  - Momomura S
FAU - Ishikawa, San-E
AU  - Ishikawa SE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Adiponectin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adiponectin/*blood
MH  - Aged
MH  - Female
MH  - Heart Failure/*blood/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Ventricular Dysfunction/*physiopathology
EDAT- 2006/11/28 09:00
MHDA- 2007/01/25 09:00
CRDT- 2006/11/28 09:00
PHST- 2006/11/28 09:00 [pubmed]
PHST- 2007/01/25 09:00 [medline]
PHST- 2006/11/28 09:00 [entrez]
AID - JST.JSTAGE/circj/70.1557 [pii]
AID - 10.1253/circj.70.1557 [doi]
PST - ppublish
SO  - Circ J. 2006 Dec;70(12):1557-62. doi: 10.1253/circj.70.1557.