PMID- 17128198
OWN - NLM
STAT- MEDLINE
DCOM- 20070209
LR  - 20130304
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 21
IP  - 1
DP  - 2007 Jan
TI  - HLA-identical sibling allogeneic peripheral blood stem cell transplantation with 
      reduced intensity conditioning compared to autologous peripheral blood stem cell 
      transplantation for elderly patients with de novo acute myeloid leukemia.
PG  - 129-35
AB  - We conducted a retrospective registry-based analysis to compare the outcome of 
      361 allogeneic human leukocyte antigen (HLA)-identical peripheral blood stem cell 
      transplants (PBSCT) with reduced intensity conditioning (RIC) to that of 1369 
      autologous (auto) PBSCT in patients aged 50 years or older with de novo acute 
      myeloid leukemia (AML), performed from 1997 until 2003 and reported to the 
      European Group for Blood and Marrow Transplantation. Median age was 58 and 57 
      years in the RIC and auto groups, respectively. RIC patients had more advanced 
      disease at the time of transplant. At a median follow-up of 24 months for RIC and 
      16 months for auto, multivariate analysis showed a lower risk for relapse (RR 
      0.77, P=0.013) without increased non-relapse mortality (NRM) in RIC patients (RR 
      1.26, P=0.28). Moreover, leukemia-free survival (RR 1.22, P=0.02) and overall 
      survival (OS) (RR 1.32, P=0.005) were superior in the RIC group. In patients in 
      1st (CR), fewer relapses were counterbalanced by significantly increased NRM. 
      Therefore, there was no survival advantage in this subgroup. In patients in 2nd 
      or subsequent CR, LFS and OS were superior in the RIC group. RIC transplants show 
      encouraging results in this older patient population with de novo AML.
FAU - Herr, A-L
AU  - Herr AL
AD  - Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
FAU - Labopin, M
AU  - Labopin M
FAU - Blaise, D
AU  - Blaise D
FAU - Milpied, N
AU  - Milpied N
FAU - Potter, M
AU  - Potter M
FAU - Michallet, M
AU  - Michallet M
FAU - Heit, W
AU  - Heit W
FAU - Ferrara, F
AU  - Ferrara F
FAU - Esteve, J
AU  - Esteve J
FAU - Arcese, W
AU  - Arcese W
FAU - Ehninger, G
AU  - Ehninger G
FAU - Rowe, J M
AU  - Rowe JM
FAU - Kobbe, G
AU  - Kobbe G
FAU - Rosselet, A
AU  - Rosselet A
FAU - Bunjes, D
AU  - Bunjes D
FAU - Rio, B
AU  - Rio B
FAU - Brune, M
AU  - Brune M
FAU - Nagler, A
AU  - Nagler A
FAU - Gorin, N C
AU  - Gorin NC
FAU - Frassoni, F
AU  - Frassoni F
FAU - Rocha, V
AU  - Rocha V
CN  - Acute Leukemia Working Party or the European Group for Blood and Marrow 
      Transplantation
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20061123
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Aged
MH  - Female
MH  - HLA Antigens/genetics/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukemia, Myeloid, Acute/immunology/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - *Peripheral Blood Stem Cell Transplantation
MH  - Recurrence
MH  - Retrospective Studies
MH  - Siblings
MH  - Survival Analysis
MH  - Transplantation Conditioning
MH  - Transplantation, Autologous
MH  - Transplantation, Homologous
EDAT- 2006/11/28 09:00
MHDA- 2007/02/10 09:00
CRDT- 2006/11/28 09:00
PHST- 2006/11/28 09:00 [pubmed]
PHST- 2007/02/10 09:00 [medline]
PHST- 2006/11/28 09:00 [entrez]
AID - 2404461 [pii]
AID - 10.1038/sj.leu.2404461 [doi]
PST - ppublish
SO  - Leukemia. 2007 Jan;21(1):129-35. doi: 10.1038/sj.leu.2404461. Epub 2006 Nov 23.