PMID- 1712861
OWN - NLM
STAT- MEDLINE
DCOM- 19910819
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 65
IP  - 8
DP  - 1991 Aug
TI  - Lack of enhancing effect of human anti-human immunodeficiency virus type 1 
      (HIV-1) antibody on HIV-1 infection of human blood monocytes and peritoneal 
      macrophages.
PG  - 4309-16
AB  - The influence of human anti-human immunodeficiency virus type 1 (HIV-1) antibody 
      on HIV-1 infection of freshly isolated normal human peritoneal macrophages and 
      blood monocytes was examined. Each of 14 HIV antibody-positive human serum 
      samples was found to block the infection of four virus isolates (human T-cell 
      lymphotropic virus type IIIBa-L [HTLV-IIIBa-L], HTLV-IIIB, D.U. 6587-7, and D.U. 
      7887-8) at serum dilutions ranging from 10(-1) to 10(-2). Three of these isolates 
      (HTLV-IIIBa-L, D.U. 6587-7, and D.U. 7887-8) infected cultures of monocytes and 
      macrophages rapidly and produced high levels of virus reverse transcriptase and 
      p24 antigen. A fourth virus isolate (HTLV-IIIB) infected the monocytes and 
      macrophages more slowly and produced low levels of viral protein. More dilute HIV 
      antibody-positive sera had no significant effect on the overall level or rate of 
      virus infection or expression. Complement did not appear to influence the course 
      of infection by any combination of antisera or virus examined. Successful HIV-1 
      infection of the peritoneal macrophages and blood monocytes under the conditions 
      tested showed strict dependence on CD4 since a recombinant CD4 polypeptide and an 
      anti-CD4 monoclonal antibody effectively blocked the process.
FAU - Shadduck, P P
AU  - Shadduck PP
AD  - Department of Surgery, Duke University, Durham, North Carolina.
FAU - Weinberg, J B
AU  - Weinberg JB
FAU - Haney, A F
AU  - Haney AF
FAU - Bartlett, J A
AU  - Bartlett JA
FAU - Langlois, A J
AU  - Langlois AJ
FAU - Bolognesi, D P
AU  - Bolognesi DP
FAU - Matthews, T J
AU  - Matthews TJ
LA  - eng
GR  - AI 07922/AI/NIAID NIH HHS/United States
GR  - AR 39162/AR/NIAMS NIH HHS/United States
GR  - CA 09307/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (HIV Antibodies)
RN  - 9007-36-7 (Complement System Proteins)
RN  - EC 2.7.7.49 (RNA-Directed DNA Polymerase)
SB  - IM
MH  - Cells, Cultured
MH  - Complement System Proteins/physiology
MH  - Fluorescent Antibody Technique
MH  - HIV Antibodies/*immunology/physiology
MH  - HIV-1/*immunology/physiology
MH  - Humans
MH  - Kinetics
MH  - Macrophages/*microbiology
MH  - Monocytes/*microbiology
MH  - Peritoneal Cavity/cytology
MH  - RNA-Directed DNA Polymerase/biosynthesis
PMC - PMC248869
EDAT- 1991/08/01 00:00
MHDA- 1991/08/01 00:01
PMCR- 1991/08/01
CRDT- 1991/08/01 00:00
PHST- 1991/08/01 00:00 [pubmed]
PHST- 1991/08/01 00:01 [medline]
PHST- 1991/08/01 00:00 [entrez]
PHST- 1991/08/01 00:00 [pmc-release]
AID - 10.1128/JVI.65.8.4309-4316.1991 [doi]
PST - ppublish
SO  - J Virol. 1991 Aug;65(8):4309-16. doi: 10.1128/JVI.65.8.4309-4316.1991.