PMID- 17129180
OWN - NLM
STAT- MEDLINE
DCOM- 20070613
LR  - 20221207
IS  - 0732-0582 (Print)
IS  - 0732-0582 (Linking)
VI  - 25
DP  - 2007
TI  - TSLP: an epithelial cell cytokine that regulates T cell differentiation by 
      conditioning dendritic cell maturation.
PG  - 193-219
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that have the 
      ability to sense infection and tissue stress, sample and present antigen to T 
      lymphocytes, and induce different forms of immunity and tolerance. The functional 
      versatility of DCs depends on their remarkable ability to translate collectively 
      the information from both the invading microbes and their resident tissue 
      microenvironments and then make an appropriate immune response. Recent progress 
      in understanding TLR biology has illuminated the mechanisms by which DCs link 
      innate and adaptive antimicrobial immune responses. However, how tissue 
      microenvironments shape the function of DCs has remained elusive. Recent studies 
      of TSLP (thymic stromal lymphopoietin), an epithelial cell-derived cytokine that 
      strongly activates DCs, provide evidence at a molecular level that epithelial 
      cells/tissue microenvironments directly communicate with DCs. We review recent 
      progress on how TSLP expressed within thymus and peripheral lymphoid and 
      nonlymphoid tissues regulates DC-mediated central tolerance, peripheral T cell 
      homeostasis, and inflammatory Th2 responses.
FAU - Liu, Yong-Jun
AU  - Liu YJ
AD  - Department of Immunology, Center of Cancer Immunology Research, University of 
      Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. yjliu@mdanderson.org
FAU - Soumelis, Vasilli
AU  - Soumelis V
FAU - Watanabe, Norihiko
AU  - Watanabe N
FAU - Ito, Tomoki
AU  - Ito T
FAU - Wang, Yui-Hsi
AU  - Wang YH
FAU - Malefyt, Rene de Waal
AU  - Malefyt Rde W
FAU - Omori, Miyuki
AU  - Omori M
FAU - Zhou, Baohua
AU  - Zhou B
FAU - Ziegler, Steven F
AU  - Ziegler SF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (Cytokines)
RN  - 0 (Toll-Like Receptors)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Cell Differentiation/*immunology
MH  - Cytokines/*immunology
MH  - Dendritic Cells/*immunology
MH  - Epithelial Cells/*immunology
MH  - Homeostasis/immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunity, Innate
MH  - Infections/immunology
MH  - Inflammation/immunology
MH  - Lymphoid Tissue/immunology
MH  - Th2 Cells/*immunology
MH  - Toll-Like Receptors/immunology
MH  - Thymic Stromal Lymphopoietin
RF  - 104
EDAT- 2006/11/30 09:00
MHDA- 2007/06/15 09:00
CRDT- 2006/11/30 09:00
PHST- 2006/11/30 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2006/11/30 09:00 [entrez]
AID - 10.1146/annurev.immunol.25.022106.141718 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 2007;25:193-219. doi: 10.1146/annurev.immunol.25.022106.141718.