PMID- 17130243
OWN - NLM
STAT- MEDLINE
DCOM- 20070305
LR  - 20181113
IS  - 0270-7306 (Print)
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Linking)
VI  - 27
IP  - 3
DP  - 2007 Feb
TI  - Murine CXCL14 is dispensable for dendritic cell function and localization within 
      peripheral tissues.
PG  - 983-92
AB  - Dendritic cells (DCs) have long been recognized as key regulators of immune 
      responses. However, the process of their recruitment to peripheral tissues and 
      turnover during homeostasis remains largely unknown. The chemokine CXCL14 (BRAK) 
      is constitutively expressed in skin and other epithelial tissues. Recently, the 
      human chemokine was proposed to play a role in the homeostatic recruitment of 
      macrophage and/or DC precursors toward the periphery, such as skin. Although so 
      far no physiological function could be demonstrated for the murine CXCL14, it 
      shows a remarkable homology to the human chemokine. In order to elucidate the in 
      vivo role of CXCL14, we generated a mouse defective for this chemokine. We 
      studied various components of the immune system with emphasis on 
      monocytes/macrophages and DC/Langerhans cell (LC) populations in different 
      tissues during steady state but did not find a significant difference between 
      knockout (CXCL14(-)(/)(-)) and control mice. Functionally, LCs were able to 
      become activated, to migrate out of skin, and to elicit a delayed type of 
      hypersensitivity reaction. Overall, our data indicate that murine CXCL14 is 
      dispensable for the homeostatic recruitment of antigen-presenting cells toward 
      the periphery and for LC functionality.
FAU - Meuter, Simone
AU  - Meuter S
AD  - Department of Medical Biochemistry and Immunology, Henry Wellcome Building, 
      School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United 
      Kingdom.
FAU - Schaerli, Patrick
AU  - Schaerli P
FAU - Roos, Regula Stuber
AU  - Roos RS
FAU - Brandau, Oliver
AU  - Brandau O
FAU - Bosl, Michael R
AU  - Bosl MR
FAU - von Andrian, Ulrich H
AU  - von Andrian UH
FAU - Moser, Bernhard
AU  - Moser B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061127
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (CXCL14 protein, mouse)
RN  - 0 (Chemokines, CXC)
SB  - IM
MH  - Animals
MH  - Breeding
MH  - Cell Count
MH  - *Cell Movement
MH  - Chemokines, CXC/deficiency/*metabolism
MH  - Dendritic Cells/*cytology/immunology
MH  - Epithelium/immunology
MH  - Female
MH  - Gene Targeting
MH  - Inflammation
MH  - Langerhans Cells/cytology/immunology
MH  - Lymphoid Tissue/*cytology/immunology
MH  - Macrophages, Peritoneal/cytology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Skin/*cytology/immunology/pathology
MH  - Wound Healing
PMC - PMC1800689
EDAT- 2006/11/30 09:00
MHDA- 2007/03/06 09:00
PMCR- 2007/06/01
CRDT- 2006/11/30 09:00
PHST- 2006/11/30 09:00 [pubmed]
PHST- 2007/03/06 09:00 [medline]
PHST- 2006/11/30 09:00 [entrez]
PHST- 2007/06/01 00:00 [pmc-release]
AID - MCB.01648-06 [pii]
AID - 1648-06 [pii]
AID - 10.1128/MCB.01648-06 [doi]
PST - ppublish
SO  - Mol Cell Biol. 2007 Feb;27(3):983-92. doi: 10.1128/MCB.01648-06. Epub 2006 Nov 
      27.