PMID- 17130552
OWN - NLM
STAT- MEDLINE
DCOM- 20070110
LR  - 20171116
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1079
DP  - 2006 Oct
TI  - T cell immunity to glutamic acid decarboxylase in fulminant type 1 diabetes 
      without significant elevation of serum amylase.
PG  - 181-5
AB  - We encountered three patients with fulminant type 1 diabetes whose serum amylase 
      levels were not elevated and evaluated their immunological characteristics. 
      Although all three patients had no antibodies to islet antigens including 
      glutamic acid decarboxylase (GAD), GAD-reactive T lymphocytes were detected in 
      two patients. Combined with the findings that human leukocyte antigen (HLA) class 
      II haplotype associated with fulminant type 1 diabetes is the same as that of 
      autoimmune type 1 diabetes, an immune process similar to autoimmune type 1 
      diabetes may be involved in at least a part of fulminant type 1 diabetes.
FAU - Aoki, Kanemi
AU  - Aoki K
AD  - Department of Internal Medicine, Division of Endocrinology and Metabolism, Showa 
      University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba, Yokohama, Kanagawa, Japan 
      227-8501.
FAU - Taniyama, Matsuo
AU  - Taniyama M
FAU - Nagayama, Chieko
AU  - Nagayama C
FAU - Oikawa, Yoichi
AU  - Oikawa Y
FAU - Shimada, Akira
AU  - Shimada A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (CD28 Antigens)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Recombinant Proteins)
RN  - 20350-15-6 (Brefeldin A)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 3.2.1.- (Amylases)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Adult
MH  - Amylases/blood
MH  - Antibodies, Monoclonal/pharmacology
MH  - Brefeldin A/pharmacology
MH  - CD28 Antigens/metabolism
MH  - CD4-Positive T-Lymphocytes/enzymology/metabolism
MH  - Cell Count
MH  - Diabetes Mellitus, Type 1/blood/*enzymology/*immunology/pathology
MH  - Female
MH  - Flow Cytometry
MH  - Glutamate Decarboxylase/genetics/*immunology
MH  - HLA-DR4 Antigen/genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/analysis/immunology
MH  - Histocompatibility Antigens Class II/analysis/immunology
MH  - Humans
MH  - Interferon-gamma/biosynthesis
MH  - Leukocytes, Mononuclear/drug effects/metabolism
MH  - Male
MH  - Middle Aged
MH  - Recombinant Proteins/immunology
MH  - T-Lymphocytes/*enzymology/*immunology
MH  - Time Factors
EDAT- 2006/11/30 09:00
MHDA- 2007/01/11 09:00
CRDT- 2006/11/30 09:00
PHST- 2006/11/30 09:00 [pubmed]
PHST- 2007/01/11 09:00 [medline]
PHST- 2006/11/30 09:00 [entrez]
AID - 1079/1/181 [pii]
AID - 10.1196/annals.1375.028 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2006 Oct;1079:181-5. doi: 10.1196/annals.1375.028.