PMID- 17130560
OWN - NLM
STAT- MEDLINE
DCOM- 20070110
LR  - 20151119
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1079
DP  - 2006 Oct
TI  - MHC class I chain-related gene-A is associated with IA2 and IAA but not GAD in 
      Swedish type 1 diabetes mellitus.
PG  - 229-39
AB  - In type 1 diabetes mellitus (T1DM), the frequency of antibodies against insulin 
      (IAA), glutamic acid decarboxylase-65 (GAD65), ICA512/IA2 (IA2), and islet cell 
      antigens (ICA) vary with human leukocyte antigen (HLA) composition of the 
      patient. IAA, IA2 autoantibodies, and ICA are increased in DQ8 positives; GAD65 
      antibodies are increased in DQ2 positives. MHC class I chain-related gene-A 
      (MICA) is another genetic marker that has been proposed to be associated with 
      T1DM. In this article, we looked at microsatellite polymorphism of MICA and its 
      association with autoantibodies (IAA, IA2, and GAD65) in Swedish T1DM patients 
      and if the association explains its importance in early events in autoimmune 
      response. We studied 635 T1DM patients between 0-35 years. Frequency of MICA5/5 
      was positively associated with the formation of IAA and IA2 antibodies considered 
      individually or in combination (odds ratio [OR], 95% CI, Pc: [IAA+ versus IAA-]: 
      4.94, 2.09-11.62, <0.0005; [IA2+ versus IA2-]: 2.65, 1.52-4.59, 0.0015; [IAA 
      and/or IA2+ versus rest]: 9.83, 2.37-40.78, <0.0015; [IAA and IA2+ versus rest]: 
      3.51, 2.01-6.15, <0.0015). Also, -5.1/5.1 was increased in IAA+ patients compared 
      to IAA- patients (2.82, 1.64-4.83, <0.0005). All patients positive for -5/5 
      developed at least one of the three antibodies. Frequency of MICA5.1 was 
      decreased in IAA+ (0.54, 0.36-0.81, 0.017), in IA2A+ (0.63, 0.45-0.88, 0.04), in 
      IAA and/or IA2A+ (0.52, 0.33-0.84, 0.044), and in IAA and IA2A+ (0.55, 0.39-0.78, 
      0.0055) patients when compared with patients negative for corresponding 
      antibodies. Frequency of MICA9, 5/5.1, and 5.1/9 was decreased in IAA+ compared 
      to IAA- patients (0.51, 0.32-0.79, 0.021; 0.22, 0.11-0.44, <0.005; and 0.39, 
      0.22-0.69, 0.026, respectively). Frequency of MICA9 and -5.1/9 was also decreased 
      in IAA and/or IA2 antibody-positive patients while MICA5/5.1 decreased in 
      patients positive for IAA and IA2 antibody both together. IAA and IA2 antibodies 
      are believed to appear early during the autoimmune reaction against beta cells. 
      Thus, according to our data, MICA-5/5 and -5.1/5.1 is associated with early 
      autoimmunity in T1DM patients. Our study suggests that MICA gene polymorphism is 
      associated with autoantibody formation and that the polymorphism especially 
      MICA5/5 and -5.1/5.1 are important in early events of autoimmune reaction.
FAU - Gupta, Manu
AU  - Gupta M
AD  - Department of Molecular Medicine, Karolinska Hospital Campus, Karolinska 
      Institute, CMM; L5:01, S-17176 Stockholm, Sweden.
FAU - Graham, Jinko
AU  - Graham J
FAU - McNeeny, Brian
AU  - McNeeny B
FAU - Zarghami, Marian
AU  - Zarghami M
FAU - Landin-Olsson, Mona
AU  - Landin-Olsson M
FAU - Hagopian, William A
AU  - Hagopian WA
FAU - Palmer, Jerry
AU  - Palmer J
FAU - Lernmark, Ake
AU  - Lernmark A
FAU - Sanjeevi, Carani B
AU  - Sanjeevi CB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Autoantigens)
RN  - 0 (Biomarkers)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Insulin Antibodies)
RN  - 0 (MHC class I-related chain A)
RN  - 0 (Membrane Proteins)
RN  - EC 3.1.3.48 (PTPRN protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
RN  - EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 8)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autoantigens/*blood/immunology
MH  - Biomarkers/analysis
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*genetics/*immunology
MH  - Female
MH  - Gene Frequency
MH  - Glutamate Decarboxylase/blood
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Insulin Antibodies/*blood/immunology
MH  - Islets of Langerhans/immunology
MH  - Male
MH  - Membrane Proteins/*blood/immunology
MH  - Microsatellite Repeats/genetics
MH  - Polymorphism, Genetic
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 1
MH  - Protein Tyrosine Phosphatases/*blood/immunology
MH  - Receptor-Like Protein Tyrosine Phosphatases, Class 8
MH  - Sweden
EDAT- 2006/11/30 09:00
MHDA- 2007/01/11 09:00
CRDT- 2006/11/30 09:00
PHST- 2006/11/30 09:00 [pubmed]
PHST- 2007/01/11 09:00 [medline]
PHST- 2006/11/30 09:00 [entrez]
AID - 1079/1/229 [pii]
AID - 10.1196/annals.1375.036 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2006 Oct;1079:229-39. doi: 10.1196/annals.1375.036.