PMID- 17131419
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20131121
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 85
IP  - 2
DP  - 2007 Feb 1
TI  - Androgen regulates trkB immunolabeling in spinal motoneurons.
PG  - 303-9
AB  - Neurotrophic factors and steroid hormones have been shown to have 
      neuroprotective/neurotherapeutic effects, and it has been shown previously that 
      brain-derived neurotrophic factor (BDNF) and testosterone have a combinatorial 
      effect in the maintenance of motoneurons. Given that gonadal hormones regulate 
      the BDNF receptor, tyrosine receptor kinase B (trkB), we hypothesized that such a 
      regulatory effect could mediate the interactive effects of BDNF and testosterone. 
      Using immunohistochemical methods, we examined the frequency of cells 
      immunolabeled for trkB receptors in two populations of spinal motoneurons, the 
      hormone-sensitive, sexually dimorphic motoneurons of the spinal nucleus of the 
      bulbocavernosus (SNB) and the nondimorphic motoneurons innervating the muscles of 
      the quadriceps. In both the highly androgen-sensitive SNB motoneurons and the 
      more typical somatic motoneurons innervating the quadriceps, the frequency of 
      motoneurons intensely immunolabeled for trkB receptors was regulated by the 
      presence of testosterone. Castrated animals deprived of testosterone showed a 
      reduced frequency of intensely labeled motoneurons compared with intact animals 
      or castrated animals given testosterone replacement. This finding suggests that 
      the combinatorial effect of BDNF and testosterone in the maintenance of 
      motoneurons could occur at least in part through an androgen-mediated expression 
      of the BDNF receptor.
FAU - Osborne, M C
AU  - Osborne MC
AD  - Department of Psychological and Brain Sciences and Program in Neuroscience, 
      Indiana University, Bloomington, Indiana 47405, USA.
FAU - Verhovshek, T
AU  - Verhovshek T
FAU - Sengelaub, D R
AU  - Sengelaub DR
LA  - eng
GR  - NS047264/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Androgens)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Androgens/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Male
MH  - Motor Neurons/*metabolism
MH  - Quadriceps Muscle/*innervation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*metabolism
MH  - Spinal Cord/metabolism
MH  - Testosterone/metabolism
EDAT- 2006/11/30 09:00
MHDA- 2007/03/30 09:00
CRDT- 2006/11/30 09:00
PHST- 2006/11/30 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2006/11/30 09:00 [entrez]
AID - 10.1002/jnr.21122 [doi]
PST - ppublish
SO  - J Neurosci Res. 2007 Feb 1;85(2):303-9. doi: 10.1002/jnr.21122.