PMID- 17132141
OWN - NLM
STAT- MEDLINE
DCOM- 20070607
LR  - 20070201
IS  - 0928-8244 (Print)
IS  - 0928-8244 (Linking)
VI  - 49
IP  - 1
DP  - 2007 Feb
TI  - Detection of four lymphotropic herpesviruses in Hungarian patients with multiple 
      myeloma and lymphoma.
PG  - 62-7
AB  - It has been suggested that human herpesvirus 8 (HHV-8), also known as KSHV 
      (Kaposi's sarcoma-associated human herpesvirus), might possess a promoting effect 
      in the development and progression of monoclonal gammopathies. In this study, the 
      presence of Epstein-Barr virus (EBV), human cytomegalovirus (CMV), human 
      herpesvirus 6 (HHV-6) and human herpesvirus 8 (HHV-8) were tested in patients 
      with multiple myeloma (MM) using both serologic and nucleic acid amplification 
      techniques. The transient reactivation or continuous presence of EBV, CMV, HHV-6 
      and HHV-8 could be detected in, respectively, 36, eight, 13 and 29 of 69 MM 
      patients; nine, one, four and six of 16 monoclonal gammopathy of unknown 
      significance patients; and seven, four, zero and five of 10 Waldenstrom's 
      macroglobulinemia patients. The total number of MM patients was 95. HHV-8 
      PCR-positivity was significantly more frequent in the MM group than in the 
      control group of patients with non-Hodgkin's lymphoma (NHL). However, serologic 
      testing did not reveal significant differences between the two patient groups. 
      The number of MM patients with concomitant herpesvirus infections as detected by 
      PCR was as follows: 15 double, seven triple and two quadruple virus nucleic acid 
      positive. In 13/95 MM patients, the simultaneous presence of acute EBV infection 
      and HHV-8 PCR-positivity was detected compared with none of the control group 
      (P=0.009). These results indicate that in addition to HHV-8, the transitional 
      reactivation of EBV may also play a role in the pathogenesis of MM.
FAU - Csire, Marta
AU  - Csire M
AD  - Division of Virology, National Center for Epidemiology, Budapest, Hungary. 
      csirem@oek.antsz.hu
FAU - Mikala, Gabor
AU  - Mikala G
FAU - Peto, Monika
AU  - Peto M
FAU - Janosi, Judit
AU  - Janosi J
FAU - Juhasz, Attila
AU  - Juhasz A
FAU - Tordai, Attila
AU  - Tordai A
FAU - Jako, Janos
AU  - Jako J
FAU - Domjan, Gyula
AU  - Domjan G
FAU - Dolgos, Janos
AU  - Dolgos J
FAU - Berencsi, Gyorgy
AU  - Berencsi G
FAU - Valyi-Nagy, Istvan
AU  - Valyi-Nagy I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061121
PL  - England
TA  - FEMS Immunol Med Microbiol
JT  - FEMS immunology and medical microbiology
JID - 9315554
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Animals
MH  - Callithrix
MH  - Herpesviridae/*genetics/immunology
MH  - Herpesviridae Infections/complications/immunology/virology
MH  - Humans
MH  - Hungary
MH  - Immunoglobulin G/blood
MH  - Lymphoma/immunology/*virology
MH  - Multiple Myeloma/immunology/*virology
MH  - Polymerase Chain Reaction/methods
MH  - Serology/methods
EDAT- 2006/11/30 09:00
MHDA- 2007/06/08 09:00
CRDT- 2006/11/30 09:00
PHST- 2006/11/30 09:00 [pubmed]
PHST- 2007/06/08 09:00 [medline]
PHST- 2006/11/30 09:00 [entrez]
AID - FIM171 [pii]
AID - 10.1111/j.1574-695X.2006.00171.x [doi]
PST - ppublish
SO  - FEMS Immunol Med Microbiol. 2007 Feb;49(1):62-7. doi: 
      10.1111/j.1574-695X.2006.00171.x. Epub 2006 Nov 21.