PMID- 17132853
OWN - NLM
STAT- MEDLINE
DCOM- 20070226
LR  - 20220129
IS  - 0031-6997 (Print)
IS  - 0031-6997 (Linking)
VI  - 58
IP  - 4
DP  - 2006 Dec
TI  - International Union of Pharmacology. LXIII. Retinoid X receptors.
PG  - 760-72
AB  - The physiological effects of retinoic acids (RAs) are mediated by members of two 
      families of nuclear receptors, the retinoic acid receptors (RARs) and the 
      retinoid X receptors (RXRs), which are encoded by three distinct human genes, 
      RXRalpha, RXRbeta, and RXRgamma. RARs bind both all-trans- and 9-cis-RA, whereas 
      only the 9-cis-RA stereoisomer binds to RXRs. As RXR/RAR heterodimers, these 
      receptors control the transcription of RA target genes through binding to 
      RA-response elements. This review is focused on the structure, mode of action, 
      ligands, expression, and pharmacology of RXRs. Given their role as common 
      partners to many other members of the nuclear receptor superfamily, these 
      receptors have been the subject of intense scrutiny. Moreover, and despite 
      numerous studies since their initial discovery, RXRs remain enigmatic nuclear 
      receptors, and there is still no consensus regarding their role. Indeed, multiple 
      questions about the actual biological role of RXRs and the existence of an 
      endogenous ligand have still to be answered.
FAU - Germain, Pierre
AU  - Germain P
AD  - Centre National de la Recherche Scientifique/Institut National de la Sante et de 
      la Recherche Medicale/Universite Louis Pasteur, Illkirch, Communaute Urbaine de 
      Strasbourg, France. germain@titus.u-strasbg.fr
FAU - Chambon, Pierre
AU  - Chambon P
FAU - Eichele, Gregor
AU  - Eichele G
FAU - Evans, Ronald M
AU  - Evans RM
FAU - Lazar, Mitchell A
AU  - Lazar MA
FAU - Leid, Mark
AU  - Leid M
FAU - De Lera, Angel R
AU  - De Lera AR
FAU - Lotan, Reuben
AU  - Lotan R
FAU - Mangelsdorf, David J
AU  - Mangelsdorf DJ
FAU - Gronemeyer, Hinrich
AU  - Gronemeyer H
LA  - eng
GR  - R01 HL105278/HL/NHLBI NIH HHS/United States
GR  - P42 ES010337/ES/NIEHS NIH HHS/United States
GR  - U19 DK062434/DK/NIDDK NIH HHS/United States
GR  - R37 DK057978/DK/NIDDK NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pharmacol Rev
JT  - Pharmacological reviews
JID - 0421737
RN  - 0 (Ligands)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
SB  - IM
MH  - Animals
MH  - Gene Expression
MH  - Humans
MH  - Ligands
MH  - Mutation
MH  - Retinoid X Receptors/classification/genetics/*physiology
MH  - Retinoids/*physiology
MH  - Terminology as Topic
RF  - 112
EDAT- 2006/11/30 09:00
MHDA- 2007/02/27 09:00
CRDT- 2006/11/30 09:00
PHST- 2006/11/30 09:00 [pubmed]
PHST- 2007/02/27 09:00 [medline]
PHST- 2006/11/30 09:00 [entrez]
AID - 58/4/760 [pii]
AID - 10.1124/pr.58.4.7 [doi]
PST - ppublish
SO  - Pharmacol Rev. 2006 Dec;58(4):760-72. doi: 10.1124/pr.58.4.7.