PMID- 17132876
OWN - NLM
STAT- MEDLINE
DCOM- 20070129
LR  - 20190820
IS  - 1550-8943 (Print)
IS  - 1550-8943 (Linking)
VI  - 1
IP  - 1
DP  - 2005
TI  - Liver repair by intra- and extrahepatic progenitors.
PG  - 61-4
AB  - Despite its remarkable capacity for endogenous regeneration, the mammalian liver 
      is vulnerable to a number of chronic or acute conditions that exceed or 
      circumvent the proliferative capabilities of its mature cell complement. 
      Bipotential hepatic progenitors, or "oval cells," have been shown to contribute 
      to organ regeneration under such circumstances, both in human patients and in 
      animal models. These progenitors are attractive agents for cell therapy, but have 
      thus far proven challenging to isolate and manipulate. New reports indicating 
      that transplanted bone marrow cells (BMCs) can also generate hepatocytes and 
      contribute to liver repair have attracted considerable attention, because these 
      cells are familiar and accessible to both clinicians and scientists. Recently, 
      the issue of whether nuclear transfer (via cell fusion between donor BMC and 
      recipient hepatocyte) or previously unrecognized differentiation potential (i.e., 
      plasticity/transdifferentiation of BMC) is the primary origin of donor-derived 
      hepatocytes has generated considerable controversy. In the liver, most evidence 
      supports cell fusion as the key agent in the reversal of hepatopathology. 
      However, regardless of their origin, the frequency of hepatocyte correction 
      events is low. As is the case for the delivery of intrahepatic progenitors, 
      substantial improvements in the understanding of this process will be needed 
      before clinical application becomes practical.
FAU - Dorrell, Craig
AU  - Dorrell C
AD  - Department of Molecular and Medical Genetics, Oregon Stem Cell Center, Oregon 
      Health & Science University, Portland, OR 97239, USA.
FAU - Grompe, Markus
AU  - Grompe M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Stem Cell Rev
JT  - Stem cell reviews
JID - 101255952
SB  - IM
MH  - Animals
MH  - Cell Division
MH  - Cell Fusion
MH  - Humans
MH  - Liver/*cytology/*physiology
MH  - Liver Regeneration/*physiology
MH  - Mammals
MH  - *Stem Cell Transplantation
MH  - Stem Cells/*cytology/*physiology
RF  - 73
EDAT- 2006/11/30 09:00
MHDA- 2007/01/30 09:00
CRDT- 2006/11/30 09:00
PHST- 2006/11/30 09:00 [pubmed]
PHST- 2007/01/30 09:00 [medline]
PHST- 2006/11/30 09:00 [entrez]
AID - SCR:1:1:61 [pii]
AID - 10.1385/SCR:1:1:061 [doi]
PST - ppublish
SO  - Stem Cell Rev. 2005;1(1):61-4. doi: 10.1385/SCR:1:1:061.