PMID- 17132901
OWN - NLM
STAT- MEDLINE
DCOM- 20070212
LR  - 20181113
IS  - 1234-1983 (Print)
IS  - 1234-1983 (Linking)
VI  - 47
IP  - 4
DP  - 2006
TI  - The retinal fascin gene 2 (FSCN2)--partial structural analysis and polymorphism 
      detection in dogs with progressive retinal atrophy (PRA).
PG  - 361-4
AB  - The retinal fascin 2 gene (FSCN2) underwent a molecular analysis, a search for 
      polymorphisms and an evaluation as a candidate gene for retinopathies in dogs. 
      Specific fragments of the gene encompassing partial exon 1 and intron 1, and 
      exons 2-5 with respective introns were sequenced and these data were deposited in 
      the GenBank database. Three distinct polymorphic sites detectable with PCR-RFLP 
      were found--AM050719: g.237G>A, AM050719: g.525A>G, and AM050720: g.1071A>G. No 
      positive associations between these polymorphisms and the PRA-clinical status 
      were observed in the investigated population consisting of Poodles, American 
      Cocker Spaniels, and English Cocker Spaniels. In spite of that, the FSCN2 gene 
      remains an excellent candidate gene for retinopathies in dogs and the results can 
      contribute to further research in this field.
FAU - Horak, Pavel
AU  - Horak P
AD  - Laboratory of Animal Genomics, Institute of Animal Physiology and Genetics, 
      Rumburska 89, 277 21 Libechov, Czech Republic. horakpav@email.cz
FAU - Knoll, Ales
AU  - Knoll A
FAU - Dvorak, Josef
AU  - Dvorak J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Appl Genet
JT  - Journal of applied genetics
JID - 9514582
RN  - 0 (Carrier Proteins)
RN  - 0 (Microfilament Proteins)
RN  - 146808-54-0 (fascin)
SB  - IM
MH  - Animals
MH  - Carrier Proteins/*genetics
MH  - Dog Diseases/*genetics
MH  - Dogs
MH  - Exons
MH  - Introns
MH  - Microfilament Proteins/*genetics
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Retinitis Pigmentosa/genetics/*veterinary
EDAT- 2006/11/30 09:00
MHDA- 2007/02/13 09:00
CRDT- 2006/11/30 09:00
PHST- 2006/11/30 09:00 [pubmed]
PHST- 2007/02/13 09:00 [medline]
PHST- 2006/11/30 09:00 [entrez]
AID - 362 [pii]
AID - 10.1007/BF03194646 [doi]
PST - ppublish
SO  - J Appl Genet. 2006;47(4):361-4. doi: 10.1007/BF03194646.