PMID- 17133782
OWN - NLM
STAT- MEDLINE
DCOM- 20070313
LR  - 20170214
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 34
IP  - 5
DP  - 2006 Sep-Oct
TI  - Acarbose, an alpha-glucosidase inhibitor, decreases aortic gene expression and 
      serum levels of monocyte chemoattractant protein-1 in fructose-fed rats.
PG  - 525-30
AB  - Insulin resistance is one of the determinants of post-prandial hyperglycaemia. 
      Recently, acarbose, an alpha-glucosidase inhibitor that delays the absorption of 
      carbohydrates from the small intestine, has been found to reduce the incidence of 
      cardiovascular disease in patients with impaired glucose tolerance or diabetes. 
      However, the molecular mechanism by which acarbose inhibits cardiovascular events 
      remains unknown. In this study, we examined whether oral administration of 
      acarbose could suppress expression of monocyte chemoattractant protein-1 (MCP-1) 
      in fructose-fed rats, a widely used animal model of insulin resistance. Serum 
      MCP-1 levels were elevated in fructose-fed rats after 4 weeks. Acarbose treatment 
      for 4 weeks reduced the fructose-induced elevation of serum MCP-1 levels. 
      Acarbose treatment for 8 weeks decreased MCP-1 mRNA levels in the aortae of 
      fructose-fed rats. These results suggest that the cardioprotective effects of 
      acarbose could be due, at least in part, to the suppression of MCP-1 expression.
FAU - Nakamura, K
AU  - Nakamura K
AD  - Department of Internal Medicine, Murume University School of Medicine, Kurume, 
      Japan; 2Department of Dermatology, Faculty of Medicine, University of Toyama, 
      Toyama, Japan.
FAU - Yamagishi, S
AU  - Yamagishi S
FAU - Matsui, T
AU  - Matsui T
FAU - Yoshida, T
AU  - Yoshida T
FAU - Imaizumi, T
AU  - Imaizumi T
FAU - Makino, T
AU  - Makino T
FAU - Shimizu, T
AU  - Shimizu T
FAU - Inoue, H
AU  - Inoue H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glycoside Hydrolase Inhibitors)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (RNA, Messenger)
RN  - 30237-26-4 (Fructose)
RN  - T58MSI464G (Acarbose)
SB  - IM
MH  - Acarbose/administration & dosage/*pharmacology
MH  - Animals
MH  - Aorta/*metabolism
MH  - Cardiotonic Agents/pharmacology
MH  - Chemokine CCL2/*blood/*genetics
MH  - Diet
MH  - Fructose/administration & dosage
MH  - Gene Expression Regulation/*drug effects
MH  - *Glycoside Hydrolase Inhibitors
MH  - Hypoglycemic Agents/administration & dosage/*pharmacology
MH  - Insulin Resistance
MH  - Male
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2006/12/01 09:00
MHDA- 2007/03/14 09:00
CRDT- 2006/12/01 09:00
PHST- 2006/12/01 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2006/12/01 09:00 [entrez]
AID - 10.1177/147323000603400510 [doi]
PST - ppublish
SO  - J Int Med Res. 2006 Sep-Oct;34(5):525-30. doi: 10.1177/147323000603400510.