PMID- 17134545
OWN - NLM
STAT- MEDLINE
DCOM- 20090112
LR  - 20160818
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 35
IP  - 9
DP  - 2006 Sep
TI  - [Relationship between chromosome 8 alterations and Gleason score in prostatic 
      adenocarcinoma].
PG  - 523-8
AB  - OBJECTIVE: To study the gain of chromosome 8 and c-myc gene and lipoprotein 
      lipase gene status in prostatic adenocarcinoma of Chinese patients, and to 
      analyze the relationship between chromosome 8 alterations and Gleason score of 
      prostatic cancer. METHODS: Formalin-fixed, paraffin-embedded prostatic biopsy 
      tissues from 34 Chinese patients with untreated prostatic adenocarcinoma were 
      studied by three-color fluorescence in situ hybridization (FISH) using 
      ProVysion(TM) probe kit. The materials included 1 case with Gleason score 5, 10 
      cases with Gleason score 6, 14 cases with Gleason score 7, 4 cases with Gleason 
      score 8 and 5 cases with Gleason score 9. The relationship between Gleason score 
      and chromosome 8 aneusomy, c-myc and lipoprotein lipase gene copy number, 
      including gene amplification or deletion, were analyzed. RESULTS: Seventeen (50%) 
      of the 34 cases studied had gain of chromosome 8, while 21 cases (61.8%) had gain 
      of c-myc gene copy number, 15 cases (44.1%) had lipoprotein lipase gene monosomy, 
      23 cases (67.6%) had c-myc gene amplification, 21 cases (61.8%) had deletion of 
      lipoprotein lipase gene and 16 cases (47.1%) had lipoprotein lipase gene deletion 
      coupled with c-myc gene amplification. In general, at least one type of 
      chromosome 8 alteration was identified in 85.3% of cases (29/34). Gain of 
      chromosome 8 was strong significant associated with Gleason score (P = 0.0006). A 
      positive correlation between increased c-myc copy number and high Gleason score 
      was also noted (P = 0.0035). On the other hand, loss of lipoprotein lipase gene 
      was negatively correlated with high Gleason score (P = 0.0383). In addition, the 
      association of c-myc gene amplification with high Gleason score was noted after 
      age adjustment (P = 0.0462). CONCLUSIONS: Alterations in chromosome 8 are common 
      in prostatic adenocarcinoma occurring in Chinese patients. There is a correlation 
      between Gleason score and gain of chromosome 8, increased c-myc gene copy number, 
      c-myc gene amplification and lipoprotein lipase gene deletion. C-myc gene 
      amplification accompanied by lipoprotein lipase gene deletion is also a common 
      occurrence in prostatic cancer. Our data suggest that chromosome 8 alterations 
      may play some roles in the development and progression of prostatic 
      adenocarcinoma.
FAU - Zeng, Xuan
AU  - Zeng X
AD  - Department of Pathology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
FAU - Wu, Sha-fei
AU  - Wu SF
FAU - Xu, Qun
AU  - Xu Q
FAU - Xiao, Yu
AU  - Xiao Y
FAU - Liu, Tong-hua
AU  - Liu TH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - EC 3.1.1.34 (Lipoprotein Lipase)
SB  - IM
MH  - Adenocarcinoma/classification/*genetics/*pathology
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Gene Deletion
MH  - Gene Dosage
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lipoprotein Lipase/genetics
MH  - Male
MH  - Middle Aged
MH  - Prostatic Neoplasms/classification/genetics/*pathology
MH  - Proto-Oncogene Proteins c-myc/genetics
EDAT- 2006/12/01 09:00
MHDA- 2009/01/13 09:00
CRDT- 2006/12/01 09:00
PHST- 2006/12/01 09:00 [pubmed]
PHST- 2009/01/13 09:00 [medline]
PHST- 2006/12/01 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2006 Sep;35(9):523-8.