PMID- 1713485
OWN - NLM
STAT- MEDLINE
DCOM- 19910830
LR  - 20191028
IS  - 0778-3124 (Print)
IS  - 0778-3124 (Linking)
VI  - 99
IP  - 1
DP  - 1991 Feb
TI  - Enzymatic adaptations to treadmill training under the influence of naftidrofuryl 
      acid in diaphragm and limb muscles of old rats.
PG  - 129-34
AB  - The effects of training and naftidrofuryl treatment were observed in 21-month-old 
      Long-Evans rats. Rats were injected intraperitoneally twice daily for 8 weeks 
      with 7 mg.kg-1 of naftidrofuryl acid (SN, TN), or with 7 mg.kg-1 fumaric acid (SC 
      and TC) or used as solvent. Training groups (TC, TN) started a progressive 8-week 
      training programme of treadmill exercise. The activities of lactate dehydrogenase 
      (LDH), hexokinase (HK), citrate synthase (CS) and 
      3-hydroxyacyl-Co-A-dehydrogenase (HAD), were measured in Soleus (SOL), Extensor 
      Digitorum Longus (EDL) and Diaphragm (DIA) muscles. The mean VO2max value was 65 
      ml.min-1.kg-1 for 21-month-old rats. The training protocol induced increases in 
      the mean VO2max values in the TC and TN groups, 71.8 and 74.4 ml.min-1.kg-1. In 
      sedentary groups (SN), naftidrofuryl increased enzymatic activities (HK, CS, HAD) 
      in the three muscles examined. When the animals underwent 8 weeks of physical 
      training, the enzymatic activities (HK, CS, HAD) increased in SOL, EDL and DIA. 
      When training was combined with naftidrofuryl treatment the increases in 
      enzymatic activities were greater than those induced by training alone. However, 
      the total changes did not differ for the sum of the changes produced by each 
      condition alone.
FAU - Sanchez, J
AU  - Sanchez J
AD  - Laboratoire de Physiologie du Travail-UA 385-CNRS, Faculte de Medecine, 
      Pitie-Salpetriere, Universite Pierre et Marie Curie, Paris, France.
FAU - Sarue, A M
AU  - Sarue AM
FAU - Brunet, A
AU  - Brunet A
FAU - Monod, H
AU  - Monod H
LA  - eng
PT  - Journal Article
PL  - Belgium
TA  - Arch Int Physiol Biochim Biophys
JT  - Archives internationales de physiologie, de biochimie et de biophysique
JID - 9111069
RN  - 42H8PQ0NMJ (Nafronyl)
RN  - EC 1.1.1.- (3-Hydroxyacyl CoA Dehydrogenases)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - 3-Hydroxyacyl CoA Dehydrogenases/metabolism
MH  - Aging/*metabolism
MH  - Animals
MH  - Body Weight
MH  - Citrate (si)-Synthase/metabolism
MH  - Diaphragm/drug effects/enzymology
MH  - Hexokinase/metabolism
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Muscles/drug effects/*enzymology
MH  - Nafronyl/*pharmacology
MH  - *Physical Conditioning, Animal
MH  - Physical Exertion/physiology
MH  - Rats
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
AID - 10.3109/13813459109145915 [doi]
PST - ppublish
SO  - Arch Int Physiol Biochim Biophys. 1991 Feb;99(1):129-34. doi: 
      10.3109/13813459109145915.