PMID- 17135743
OWN - NLM
STAT- MEDLINE
DCOM- 20070216
LR  - 20131121
IS  - 1018-8665 (Print)
IS  - 1018-8665 (Linking)
VI  - 213
IP  - 4
DP  - 2006
TI  - Drug-induced hypersensitivity syndrome due to mexiletine hydrochloride associated 
      with reactivation of human herpesvirus 7.
PG  - 341-4
AB  - It has been suggested that reactivation of human herpesvirus 6 (HHV-6) infection 
      may be involved in the pathogenesis of drug-induced hypersensitivity syndrome. We 
      report a 45-year-old Japanese man who developed a generalized papuloerythematous 
      rash, fever, hepatitis, lymphadenopathy and lymphocytosis with an increased 
      number of atypical lymphocytes. He was diagnosed with DIHS due to mexiletine 
      hydrochloride based on laboratory data, results of a patch test and the clinical 
      course of his complaint, and was treated with systemic steroids. In order to 
      determine whether HHV-6 or -7 was associated with the patient's disease, 
      serological assays and PCR were carried out. Significant increases in antibody 
      titers against HHV-6 and -7 were observed from day 12 to 24. From PCR analysis, 
      none of the peripheral blood mononuclear cells or skin tissue samples contained 
      HHV-6 DNA. All samples, however, were found to contain HHV-7 DNA. Reactivation of 
      HHV-7 could be responsible for drug-induced hypersensitivity syndrome.
CI  - Copyright (c) 2006 S. Karger AG, Basel.
FAU - Yagami, Akiko
AU  - Yagami A
AD  - Department of Dermatology, Fujita Health University, School of Medicine, Toyoake, 
      Aichi, Japan. atomi@fujita-hu.ac.jp
FAU - Yoshikawa, Tetsushi
AU  - Yoshikawa T
FAU - Asano, Yoshizo
AU  - Asano Y
FAU - Koie, Shin
AU  - Koie S
FAU - Shiohara, Tetsuo
AU  - Shiohara T
FAU - Matsunaga, Kayoko
AU  - Matsunaga K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Switzerland
TA  - Dermatology
JT  - Dermatology (Basel, Switzerland)
JID - 9203244
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 1U511HHV4Z (Mexiletine)
SB  - IM
CIN - Dermatology. 2006;213(4):273-6. PMID: 17135730
MH  - Anti-Arrhythmia Agents/*adverse effects
MH  - Antibodies, Viral/analysis
MH  - DNA, Viral/analysis
MH  - Drug Eruptions/etiology/virology
MH  - Drug Hypersensitivity/*etiology/virology
MH  - Herpesvirus 6, Human/immunology
MH  - Herpesvirus 7, Human/*drug effects/genetics/immunology
MH  - Humans
MH  - Immunoglobulin G/analysis
MH  - Leukocytosis/etiology/virology
MH  - Male
MH  - Mexiletine/adverse effects
MH  - Middle Aged
MH  - Roseolovirus Infections/diagnosis/immunology
MH  - Syndrome
MH  - Virus Activation/*drug effects
EDAT- 2006/12/01 09:00
MHDA- 2007/02/17 09:00
CRDT- 2006/12/01 09:00
PHST- 2006/01/19 00:00 [received]
PHST- 2006/04/28 00:00 [accepted]
PHST- 2006/12/01 09:00 [pubmed]
PHST- 2007/02/17 09:00 [medline]
PHST- 2006/12/01 09:00 [entrez]
AID - 96200 [pii]
AID - 10.1159/000096200 [doi]
PST - ppublish
SO  - Dermatology. 2006;213(4):341-4. doi: 10.1159/000096200.