PMID- 17136960
OWN - NLM
STAT- MEDLINE
DCOM- 20070222
LR  - 20191110
IS  - 1541-2555 (Print)
IS  - 1541-2563 (Linking)
VI  - 2
IP  - 1
DP  - 2005 Mar
TI  - Challenges associated with estimating minimal clinically important differences in 
      COPD-the NHLBI perspective.
PG  - 43-6
AB  - Chronic Obstructive Pulmonary Disease (COPD) is a common lung disease that 
      exemplifies the value, as well as the difficulties and challenges, of using 
      minimal clinically important differences (MCID) in clinical research. Development 
      and validation of better endpoints for clinical studies is critical to research 
      progress in COPD. However, the clinical, genetic, and pharmacological 
      heterogeneity of the COPD patient population complicates attempts to define and 
      validate MCIDs for COPD. It is difficult to identify a single measurable outcome 
      that reflects the many components of the COPD patient's health state. Acute 
      exacerbations of symptoms, which COPD patients often experience, present another 
      challenge in the development of MCIDs for this disease. Consequently, the NHLBI 
      does not require the use of MCIDs in clinical research. This allows research on 
      the causes, prevention and diagnosis of COPD and use of endpoints for which an 
      MCID is not yet known. It is important for the scientific community to reach 
      agreement on what is a meaningful MCID in therapeutic trials for COPD. Further 
      research into the concept of the MCID and its application should enable 
      therapeutic trials in COPD to yield knowledge that is more effectively translated 
      into improved public health.
FAU - Kiley, James P
AU  - Kiley JP
AD  - Division of Lung Diseases, National Heart, Lung, and Blood Institute, National 
      Institutes of Health, Suite 10018, 6701 Rockledge Drive, Bethesda, Maryland 
      20892, USA. KileyJ@nih.gov
FAU - Sri Ram, J
AU  - Sri Ram J
FAU - Croxton, Thomas L
AU  - Croxton TL
FAU - Weinmann, Gail G
AU  - Weinmann GG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - COPD
JT  - COPD
JID - 101211769
SB  - IM
MH  - Data Interpretation, Statistical
MH  - Humans
MH  - Pulmonary Disease, Chronic Obstructive/complications/*therapy
MH  - Treatment Outcome
RF  - 10
EDAT- 2006/12/02 09:00
MHDA- 2007/02/23 09:00
CRDT- 2006/12/02 09:00
PHST- 2006/12/02 09:00 [pubmed]
PHST- 2007/02/23 09:00 [medline]
PHST- 2006/12/02 09:00 [entrez]
AID - 10.1081/copd-200050649 [doi]
PST - ppublish
SO  - COPD. 2005 Mar;2(1):43-6. doi: 10.1081/copd-200050649.