PMID- 17136963
OWN - NLM
STAT- MEDLINE
DCOM- 20070222
LR  - 20220330
IS  - 1541-2555 (Print)
IS  - 1541-2563 (Linking)
VI  - 2
IP  - 1
DP  - 2005 Mar
TI  - Assessing the minimally clinically significant difference: scientific 
      considerations, challenges and solutions.
PG  - 57-62
AB  - The scientific considerations surrounding the estimation of a minimally 
      clinically important difference (MCID) are a myriad and challenging. There are a 
      considerable number of hurdles to overcome. The good news is that there are 
      solutions to virtually every one of the scientific hurdles. This paper intends to 
      set out the issues, identify the challenges, and offer solutions so that the 
      state of the science may move forward. The ultimate outcome of the paper may not 
      be to provide a definitive answer for estimating the MCID in every situation, but 
      it should provide a starting point and advice for a process or set of guidelines 
      that may be followed toward achieving this goal. The paper begins with a brief 
      synthesis of the literature and state of the science at the time of publication. 
      The relationship between the process for determining MCIDs for other endpoints, 
      such as tumor response or complete blood culture (CBC) variables, versus toxicity 
      and QOL-related variables is described. The ultimate lessons to be learned from 
      this exercise are: 1. There are many methods available to ascertaining an MCID. 
      None are perfect, but all are useful. 2. All methods converge to similar answers. 
      Supplementary information may refine answers from one or more of the methods. 3. 
      Clinical opinion and patient subjective response should trump statistical theory. 
      4. A process of MCID estimation involving all approaches to produce a potential 
      range with sensitivity analyses is the optimal solution to producing an MCID 
      based on the most complete knowledge possible.
FAU - Sloan, Jeff A
AU  - Sloan JA
AD  - Mayo Clinic Rochester, Cancer Center Statistics, 200 1st St SW, Rochester, 
      Minnesota 55905, USA. jsloan@mayo.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - COPD
JT  - COPD
JID - 101211769
SB  - IM
MH  - Data Interpretation, Statistical
MH  - Humans
MH  - Pulmonary Disease, Chronic Obstructive/*therapy
MH  - Quality of Life
MH  - Treatment Outcome
RF  - 21
EDAT- 2006/12/02 09:00
MHDA- 2007/02/23 09:00
CRDT- 2006/12/02 09:00
PHST- 2006/12/02 09:00 [pubmed]
PHST- 2007/02/23 09:00 [medline]
PHST- 2006/12/02 09:00 [entrez]
AID - 10.1081/copd-200053374 [doi]
PST - ppublish
SO  - COPD. 2005 Mar;2(1):57-62. doi: 10.1081/copd-200053374.