PMID- 1713715
OWN - NLM
STAT- MEDLINE
DCOM- 19910904
LR  - 20220310
IS  - 0166-2236 (Print)
IS  - 0166-2236 (Linking)
VI  - 14
IP  - 5
DP  - 1991 May
TI  - The changing scene of neurotrophic factors.
PG  - 165-70
AB  - The purification of brain-derived neurotrophic factor (BDNF), the elucidation of 
      its primary structure, and the subsequent identification of neurotrophin-3 (NT-3) 
      ended the monopoly of NGF as the only well-characterized, target-derived 
      neurotrophic molecule. NGF, BDNF and NT-3 are members of a gene family called 
      neurotrophins. They have strictly conserved domains that determine their basic 
      structure. However, they also have distinctly variable domains that determine 
      their different neuronal specificity mediated by different high affinity 
      receptors, and that share a common low affinity subunit. These similarities and 
      dissimilarities between the members of the neurotrophin gene family are also 
      reflected by their regional distribution, cellular localization and developmental 
      regulation. In this article the neurotrophins are compared with ciliary 
      neurotrophic factor (CNTF), which is a representative of the category of 
      neurotrophic molecules that, according to their regional distribution, 
      developmental expression and cellular localization, do not fulfil the criteria of 
      a target-derived neurotrophic molecule. The physiological and pathophysiological 
      functions of neurotrophins and CNTF are discussed in the context of their 
      potential use for the treatment of traumatic and degenerative diseases of the 
      peripheral and central nervous systems.
FAU - Thoenen, H
AU  - Thoenen H
AD  - Max-Planck-Institute for Psychiatry, Dept of Neurochemistry, Planegg-Martinsried, 
      FRG.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Neurosci
JT  - Trends in neurosciences
JID - 7808616
RN  - 0 (Neurotransmitter Agents)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Nervous System Physiological Phenomena
MH  - Neurotransmitter Agents/*physiology
RF  - 53
EDAT- 1991/05/01 00:00
MHDA- 1991/05/01 00:01
CRDT- 1991/05/01 00:00
PHST- 1991/05/01 00:00 [pubmed]
PHST- 1991/05/01 00:01 [medline]
PHST- 1991/05/01 00:00 [entrez]
AID - 0166-2236(91)90097-E [pii]
AID - 10.1016/0166-2236(91)90097-e [doi]
PST - ppublish
SO  - Trends Neurosci. 1991 May;14(5):165-70. doi: 10.1016/0166-2236(91)90097-e.