PMID- 17138547
OWN - NLM
STAT- MEDLINE
DCOM- 20090417
LR  - 20211203
IS  - 0253-9772 (Print)
IS  - 0253-9772 (Linking)
VI  - 28
IP  - 12
DP  - 2006 Dec
TI  - [Research advances on the relationship of PI3-kinase/Akt/mTOR pathway and 
      epigenetic modification].
PG  - 1585-90
AB  - The mammalian target of rapamycin (mTOR) has been shown to link growth factor 
      signaling and posttranscriptional control of protein translation through 
      activation of the PI3K/Akt pathway, which is frequently involved in cell cycle 
      progression. The inhibition of mTOR has promising potential in anticancer and 
      immunosuppressive therapies, and additional phase II clinical trials are ongoing. 
      Epigenetic modification, which involves DNA methylation, histone modification and 
      chromatin remodeling, as well as the recently described RNAi mechanism, can 
      initiate the formation of silenced chromatin. Persistent activation or inhibition 
      of the mTOR pathway may affect epigenetic modification. In this paper, we 
      reviewed the research advances in the relationship between PI3K/Akt/mTOR and 
      epigenetic modification.
FAU - Wang, Xia
AU  - Wang X
AD  - Renji Hospital, Medical Colloge of Shanghai Jiao Tong University, Shanghai 
      Institute of Disgestive Disease, Shanghai 200001, China.
FAU - Sun, Dan-Feng
AU  - Sun DF
FAU - Fang, Jing-Yuan
AU  - Fang JY
LA  - chi
PT  - Journal Article
PT  - Review
PL  - China
TA  - Yi Chuan
JT  - Yi chuan = Hereditas
JID - 9436478
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Drug Discovery
MH  - *Epigenesis, Genetic
MH  - Humans
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Protein Kinases/*metabolism
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases
RF  - 44
EDAT- 2006/12/02 09:00
MHDA- 2009/04/18 09:00
CRDT- 2006/12/02 09:00
PHST- 2006/12/02 09:00 [pubmed]
PHST- 2009/04/18 09:00 [medline]
PHST- 2006/12/02 09:00 [entrez]
AID - 0253-9772(2006)12-1585-06 [pii]
AID - 10.1360/yc-006-1585 [doi]
PST - ppublish
SO  - Yi Chuan. 2006 Dec;28(12):1585-90. doi: 10.1360/yc-006-1585.