PMID- 17139661
OWN - NLM
STAT- MEDLINE
DCOM- 20070123
LR  - 20191210
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 55
IP  - 6
DP  - 2006 Dec 15
TI  - Development and validation of the revised Cedars-Sinai health-related quality of 
      life for rheumatoid arthritis instrument.
PG  - 856-63
AB  - OBJECTIVE: To improve accuracy and content coverage of the original 33-item 
      Cedars-Sinai Health-Related Quality of Life for Rheumatoid Arthritis Instrument 
      (CSHQ-RA). METHODS: A total of 312 RA patients from 55 sites were screened in a 
      24-week trial. Patients completed an expanded 48-item version of the CSHQ-RA, 
      Medical Outcomes Study Short Form 36 (MOS SF-36), and Stanford Health Assessment 
      Questionnaire (HAQ) Disability Index at 5 visits. The revised CSHQ-RA was created 
      based on response frequencies and distributions, item-to-item correlation, factor 
      and Rasch analysis, and input from experts. Psychometric evaluation included 
      internal consistency, test-retest reliability, convergent and discriminant 
      validity, and responsiveness. Minimum clinically important difference (MCID) was 
      also measured. RESULTS: Response rates were 93% at baseline and 71% at 12 weeks. 
      Eighty-one percent of respondents at baseline were women, mean +/- SD age was 52 
      +/- 12 years, and mean +/- SD duration of RA was 10.8 +/- 10.4 years. The revised 
      CSHQ-RA included 36 items measuring 7 domains (4 original and 3 new). All 
      Cronbach's alpha coefficients were >0.8, indicating good internal consistency. 
      Test-retest reliability measured intraclass correlation coefficients, which 
      ranged from 0.86 to 0.95. All 7 domains correlated significantly with the MOS 
      SF-36 and HAQ, indicating good convergent validity. Analysis of variance of 
      disability group scores showed good discriminant validity (P < 0.0001). The MCIDs 
      ranged from 6.2 for social well-being to 14.8 for pain/discomfort. CONCLUSION: 
      The revised CSHQ-RA was validated using a broader RA patient population. It 
      captures 3 additional domains (social well-being, pain/discomfort, and fatigue), 
      which allow for measuring all important aspects of health-related quality of 
      life.
FAU - Chiou, C F
AU  - Chiou CF
AD  - Cerner LifeSciences, Beverly Hills, California, USA.
FAU - Sherbourne, C D
AU  - Sherbourne CD
FAU - Cornelio, I
AU  - Cornelio I
FAU - Lubeck, D P
AU  - Lubeck DP
FAU - Paulus, H E
AU  - Paulus HE
FAU - Dylan, M
AU  - Dylan M
FAU - Chang, C H
AU  - Chang CH
FAU - Weisman, M H
AU  - Weisman MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
SB  - IM
MH  - Arthritis, Rheumatoid/*physiopathology/psychology
MH  - *Disability Evaluation
MH  - *Health Status
MH  - Humans
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Surveys and Questionnaires/*standards
EDAT- 2006/12/02 09:00
MHDA- 2007/01/24 09:00
CRDT- 2006/12/02 09:00
PHST- 2006/12/02 09:00 [pubmed]
PHST- 2007/01/24 09:00 [medline]
PHST- 2006/12/02 09:00 [entrez]
AID - 10.1002/art.22090 [doi]
PST - ppublish
SO  - Arthritis Rheum. 2006 Dec 15;55(6):856-63. doi: 10.1002/art.22090.