PMID- 17141183
OWN - NLM
STAT- MEDLINE
DCOM- 20070212
LR  - 20061215
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 352
IP  - 3
DP  - 2007 Jan 19
TI  - Adventitial fibroblasts are activated in the early stages of atherosclerosis in 
      the apolipoprotein E knockout mouse.
PG  - 681-8
AB  - The role of the adventitia in vascular function and vascular lesion formation has 
      been largely ignored. This study observed the activation of the adventitia and 
      specifically the fibroblasts in the development of atherosclerosis in the 
      apoE(-/-) mouse. The results showed a gradual increase in expression of collagen 
      types I and III after 2, 4, and 8 weeks of hyperlipidic diet. The earliest 
      expression of monocyte chemoattractant protein-1 (MCP-1) protein and mRNA was 
      detected in the adventitial fibroblast before the formation of intimal lesions. 
      Proliferation, too, was first found in the adventitial fibroblasts. We 
      hypothesize that the adventitial fibroblast is activated in the early stage of 
      atherosclerosis. Adventitial inflammation may be an early event in the 
      development of atherosclerotic lesions.
FAU - Xu, Fang
AU  - Xu F
AD  - Department of Pathophysiology, School of Medicine, Shandong University, Jinan 
      250012, Shandong, China.
FAU - Ji, Jian
AU  - Ji J
FAU - Li, Li
AU  - Li L
FAU - Chen, Rong
AU  - Chen R
FAU - Hu, Wei-cheng
AU  - Hu WC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061127
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Apolipoproteins E)
SB  - IM
MH  - Animals
MH  - Apolipoproteins E/genetics/metabolism
MH  - Atherosclerosis/*immunology/*pathology
MH  - Cells, Cultured
MH  - Connective Tissue/*immunology/*pathology
MH  - Disease Models, Animal
MH  - Fibroblasts/*immunology/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
EDAT- 2006/12/05 09:00
MHDA- 2007/02/13 09:00
CRDT- 2006/12/05 09:00
PHST- 2006/11/03 00:00 [received]
PHST- 2006/11/15 00:00 [accepted]
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2007/02/13 09:00 [medline]
PHST- 2006/12/05 09:00 [entrez]
AID - S0006-291X(06)02552-6 [pii]
AID - 10.1016/j.bbrc.2006.11.073 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2007 Jan 19;352(3):681-8. doi: 
      10.1016/j.bbrc.2006.11.073. Epub 2006 Nov 27.