PMID- 17141328
OWN - NLM
STAT- MEDLINE
DCOM- 20070716
LR  - 20070509
IS  - 0165-0378 (Print)
IS  - 0165-0378 (Linking)
VI  - 74
IP  - 1-2
DP  - 2007 Jun
TI  - Maternal nerve growth factor serum levels in the perinatal period.
PG  - 170-3
AB  - Neurotrophins, such as nerve growth factor (NGF) and brain-derived neurotrophic 
      factor (BDNF), are potent modulators of neuronal and immune function, and have 
      been implicated recently in diseases associated with pregnancy. In contrast to 
      serum BDNF, which is reportedly suppressed in the perinatal period, regulation of 
      NGF in the perinatal period is unknown. In this study, serum NGF concentrations 
      were measured in 40 pregnant (follow-up: 30th and 37th week of gestation, 1 week 
      and 8 weeks after childbirth) and 40 non-pregnant women. Maternal NGF serum 
      levels did not differ significantly from controls (median: 7.6 pg NGF/ml serum) 
      neither before nor after childbirth, although there was a trend towards increased 
      NGF concentrations at the 37th week of gestation (median: 12.5 pg NGF/ml serum) 
      and 1 week after childbirth (median: 11.6 pg NGF/ml serum). There was no 
      association of maternal NGF with 17beta-estradiol, progesterone, 
      dehydroepiandrosterone sulfate (DHEAS) and cortisol concentrations in maternal 
      serum, or maternal depression, as measured by the Edinburgh Postnatal Depression 
      Scale (EPDS). In the non-pregnant control group, NGF serum concentrations were 
      negatively correlated with the number of days since the first day of the 
      menstrual cycle (r=-0.32, p<0.05). In conclusion, NGF is not altered during 
      normal pregnancy on a systemic level. In addition, NGF displays a different 
      regulation compared with BDNF during the menstrual cycle.
FAU - Schulte-Herbruggen, Olaf
AU  - Schulte-Herbruggen O
AD  - Department of Psychiatry, University Medicine Berlin, Germany.
FAU - Litzke, Julia
AU  - Litzke J
FAU - Hornych, Katharina
AU  - Hornych K
FAU - Zingler, Christiana
AU  - Zingler C
FAU - Hoppner, Jacqueline
AU  - Hoppner J
FAU - Virchow, J Christian
AU  - Virchow JC
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Lommatzsch, Marek
AU  - Lommatzsch M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061201
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Female
MH  - Humans
MH  - Nerve Growth Factor/*blood
MH  - Postpartum Period/*blood
MH  - Pregnancy/*blood
EDAT- 2006/12/05 09:00
MHDA- 2007/07/17 09:00
CRDT- 2006/12/05 09:00
PHST- 2006/08/17 00:00 [received]
PHST- 2006/10/02 00:00 [revised]
PHST- 2006/10/04 00:00 [accepted]
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2007/07/17 09:00 [medline]
PHST- 2006/12/05 09:00 [entrez]
AID - S0165-0378(06)00227-0 [pii]
AID - 10.1016/j.jri.2006.10.003 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2007 Jun;74(1-2):170-3. doi: 10.1016/j.jri.2006.10.003. Epub 
      2006 Dec 1.