PMID- 17142307
OWN - NLM
STAT- MEDLINE
DCOM- 20070125
LR  - 20181113
IS  - 1072-0502 (Print)
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Linking)
VI  - 13
IP  - 6
DP  - 2006 Nov-Dec
TI  - Temporary basolateral amygdala lesions disrupt acquisition of socially 
      transmitted food preferences in rats.
PG  - 794-800
AB  - Lesions of the basolateral amygdala (BLA) have long been associated with 
      abnormalities of taste-related behaviors and with failure in a variety of taste- 
      and odor-related learning paradigms, including taste-potentiated odor aversion, 
      conditioned taste preference, and conditioned taste aversion. Still, the general 
      role of the amygdala in chemosensory learning remains somewhat controversial. In 
      particular, it has been suggested that the amygdala may not be involved in a form 
      of chemosensory learning that has recently received a substantial amount of 
      study-socially transmitted food preference (STFP). Here, we provide evidence for 
      this involvement by pharmacologically inactivating the basolateral amygdala 
      bilaterally during STFP training. The same inactivation sites that impaired taste 
      aversion learning eliminated the normally conditioned preference for a food 
      smelled on a conspecific's breath. Impairments of learned preference persisted 
      even in testing sessions in which BLA was not inactivated, and learning was 
      normal when the BLA was inactivated only during testing sessions; thus, the 
      impairment was a true acquisition deficit. In conjunction with previous results 
      from other paradigms, therefore, our data suggest that the amygdala is vital for 
      learning procedures involving pairings of potent and arbitrary chemosensory 
      stimuli.
FAU - Wang, Yunyan
AU  - Wang Y
AD  - Neuroscience Program, Brandeis University, Waltham, Massachusetts 02454, USA.
FAU - Fontanini, Alfredo
AU  - Fontanini A
FAU - Katz, Donald B
AU  - Katz DB
LA  - eng
GR  - R01 DC006666/DC/NIDCD NIH HHS/United States
GR  - DC006666/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
SB  - IM
MH  - Amygdala/*physiology
MH  - Analysis of Variance
MH  - Animals
MH  - Association Learning/*physiology
MH  - Feeding Behavior/*physiology
MH  - Female
MH  - Food Preferences/*physiology
MH  - Imitative Behavior/physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Smell/physiology
MH  - Social Environment
MH  - Taste/physiology
PMC - PMC1783634
EDAT- 2006/12/05 09:00
MHDA- 2007/01/26 09:00
PMCR- 2007/11/01
CRDT- 2006/12/05 09:00
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2007/01/26 09:00 [medline]
PHST- 2006/12/05 09:00 [entrez]
PHST- 2007/11/01 00:00 [pmc-release]
AID - 13/6/794 [pii]
AID - 10.1101/lm.397006 [doi]
PST - ppublish
SO  - Learn Mem. 2006 Nov-Dec;13(6):794-800. doi: 10.1101/lm.397006.