PMID- 17142793
OWN - NLM
STAT- MEDLINE
DCOM- 20070101
LR  - 20131121
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 20
IP  - 14
DP  - 2006 Dec
TI  - Synergistic effects of caloric restriction with maintained protein intake on 
      skeletal muscle performance in 21-month-old rats: a mitochondria-mediated 
      pathway.
PG  - 2439-50
AB  - Caloric restriction (CR) delays the onset of age-related mitochondrial 
      abnormalities but does not prevent the decline in ATP production needed to 
      sustain muscle protein fractional synthesis rate (FSR) and contractile activity. 
      We hypothesized that improving mitochondrial activity and FSR using a CR diet 
      with maintained protein intakes could enhance myofibrillar protein FSR and 
      consequently improve muscle strength in aging rats. Wistar rats (21 months old) 
      were fed either an ad libitum (AL), 40% protein-energy restricted (PER) or 40% 
      AL-isonitrogenous energy restricted (ER) diet for 5 months. ATP production, 
      electron transport chain activity, reactive oxygen species (ROS) generation, 
      protein carbonyl content and FSR were determined in both tibialis anterior (TA) 
      and soleus muscle mitochondria. Myosin and actin FSR and grip force were also 
      investigated. The ER diet led to improved mitochondrial activity and ATP 
      production in the TA and soleus muscles in comparison with PER. Furthermore, 
      mitochondrial FSR in the TA was enhanced under the ER diet but diminished under 
      the PER. Mitochondrial protein carbonyl content was decreased by both the ER and 
      PER diets. The ER diet was able to improve myosin and actin FSR and grip force. 
      Therefore, the synergistic effects of CR with maintained protein intake may help 
      to limit the progression of sarcopenia by optimizing the turnover rates and 
      functions of major proteins in skeletal muscle.
FAU - Zangarelli, Aude
AU  - Zangarelli A
AD  - INRA, UMR1019, UNH, Clermont-Ferrand, France.
FAU - Chanseaume, Emilie
AU  - Chanseaume E
FAU - Morio, Beatrice
AU  - Morio B
FAU - Brugere, Corinne
AU  - Brugere C
FAU - Mosoni, Laurent
AU  - Mosoni L
FAU - Rousset, Paulette
AU  - Rousset P
FAU - Giraudet, Christophe
AU  - Giraudet C
FAU - Patrac, Veronique
AU  - Patrac V
FAU - Gachon, Pierre
AU  - Gachon P
FAU - Boirie, Yves
AU  - Boirie Y
FAU - Walrand, Stephane
AU  - Walrand S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Dietary Proteins)
RN  - 11062-77-4 (Superoxides)
RN  - 27YLU75U4W (Phosphorus)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 3.6.4.1 (Myosins)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adenosine Triphosphate/biosynthesis
MH  - Aging
MH  - Animals
MH  - *Caloric Restriction
MH  - Dietary Proteins/*metabolism
MH  - Male
MH  - Mitochondria, Muscle/*metabolism
MH  - Muscle, Skeletal/*metabolism
MH  - Myosins/metabolism
MH  - Oxidative Stress
MH  - Oxygen/metabolism
MH  - Phosphorus/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxides/metabolism
EDAT- 2006/12/05 09:00
MHDA- 2007/01/02 09:00
CRDT- 2006/12/05 09:00
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2007/01/02 09:00 [medline]
PHST- 2006/12/05 09:00 [entrez]
AID - 20/14/2439 [pii]
AID - 10.1096/fj.05-4544com [doi]
PST - ppublish
SO  - FASEB J. 2006 Dec;20(14):2439-50. doi: 10.1096/fj.05-4544com.