PMID- 17142976
OWN - NLM
STAT- MEDLINE
DCOM- 20070212
LR  - 20190720
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 29
IP  - 12
DP  - 2006 Dec
TI  - Ginseng saponins diminish adverse vascular effects associated with chronic 
      methionine-induced hyperhomocysteinemia.
PG  - 2425-31
AB  - Recent studies have shown that Panax ginseng has a variety of beneficial effects 
      on the cardiovascular systems. Homocysteine (Hcy), which is derived from 
      L-methionine (Met), has been closely associated with the increased risk of 
      cardiovascular diseases. In the present study, we examined whether in vivo 
      long-term administration of ginseng saponins (GS), active ingredients of Panax 
      ginseng, attenuate adverse vascular effects associated with chronic Met-induced 
      hyperhomocysteinemia (H-Hcy). We found that plasma Hcy level, which was measured 
      after 30 and 60 d, in GS (100 mg/kg)+Met co-administration group was 
      significantly reduced when it was compared with Met alone treatment group. We 
      could also observe the alleviation of endothelial damages of aortic artery 
      vessels in GS (100 mg/kg)+Met co-administration group compared with Met alone 
      treatment group. We compared aortic vasocontractile and vasodilatory responses 
      between Met alone and GS (100 mg/kg)+Met co-treatment groups. We found that 
      norepinephrine-induced vasocontractile responses were greatly decreased in GS 
      (100 mg/kg)+Met co-treatment group and that carbachol-induced dilatory responses 
      were greatly enhanced in GS (100 mg/kg)+Met co-administration groups as compared 
      with Met alone treatment group. The present results indicate that in vivo 
      long-term administration of GS attenuates adverse vascular effects associated 
      with chronic Met-induced H-Hcy in rats.
FAU - Kim, Jong-Hoon
AU  - Kim JH
AD  - Department of Physiology, College of Veterinary Medicine, Chonbuk National 
      University, Ginsentology Research Laboratory, Seoul, Korea.
FAU - Cho, Soo Yeun
AU  - Cho SY
FAU - Kang, Chang-Won
AU  - Kang CW
FAU - Yoon, In-Soo
AU  - Yoon IS
FAU - Lee, Jun-Ho
AU  - Lee JH
FAU - Jeong, Sang Min
AU  - Jeong SM
FAU - Lee, Byung-Hwan
AU  - Lee BH
FAU - Lee, Joon-Hee
AU  - Lee JH
FAU - Pyo, Mi-Kyung
AU  - Pyo MK
FAU - Choi, Sun-Hye
AU  - Choi SH
FAU - Quan, Shi Fu
AU  - Quan SF
FAU - Lee, Jong-Hwan
AU  - Lee JH
FAU - Choi, Chi-Bong
AU  - Choi CB
FAU - Rhim, Hyewhon
AU  - Rhim H
FAU - Nah, Seung-Yeol
AU  - Nah SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Saponins)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - Body Weight
MH  - Heart Rate
MH  - Hyperhomocysteinemia/chemically induced/*drug therapy/physiopathology
MH  - Male
MH  - Methionine/*adverse effects
MH  - Panax/*chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - Saponins/*therapeutic use
EDAT- 2006/12/05 09:00
MHDA- 2007/02/13 09:00
CRDT- 2006/12/05 09:00
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2007/02/13 09:00 [medline]
PHST- 2006/12/05 09:00 [entrez]
AID - JST.JSTAGE/bpb/29.2425 [pii]
AID - 10.1248/bpb.29.2425 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2006 Dec;29(12):2425-31. doi: 10.1248/bpb.29.2425.