PMID- 17143015
OWN - NLM
STAT- MEDLINE
DCOM- 20070213
LR  - 20191210
IS  - 1010-4283 (Print)
IS  - 1010-4283 (Linking)
VI  - 28
IP  - 1
DP  - 2007
TI  - Serum levels of hepatocyte growth factor/scatter factor in patients with liver 
      metastases from breast cancer.
PG  - 36-44
AB  - OBJECTIVE: Recent studies have shown that the pleiotropic cytokine hepatocyte 
      growth factor/scatter factor (HGF/SF) and its receptor c-Met play major roles in 
      the malignant progression of numerous tumors. For patients with breast cancer 
      liver metastases, increased serum levels of HGF/SF have been reported. We studied 
      the relationship between the clinical course of the disease and the serum levels 
      of HGF/SF in such patients. METHODS: We examined 51 patients treated for breast 
      cancer liver metastases. Serum concentrations of HGF/SF were measured before each 
      therapy cycle and compared to the corresponding tumor marker levels. RESULTS: 
      Mean serum levels of HGF/SF in patients with liver metastases were increased 
      above the reported reference levels of primary breast cancer patients. Serum 
      levels of HGF/SF were correlated with tumor marker levels in a logarithmic 
      relation (r = 0.47, p < 0.001). In some cases serum concentrations of HGF/SF 
      changed similarly to the course of the corresponding tumor markers. CONCLUSIONS: 
      Serum levels of HGF/SF are associated with the clinical course of metastatic 
      breast cancer patients with liver metastases. Further studies are required to 
      clarify the potential value of the HGF/SF serum concentration as a tumor marker. 
      HGF/SF and its receptor c-Met should be further evaluated as therapeutic targets.
FAU - Eichbaum, Michael H R
AU  - Eichbaum MH
AD  - Department of Gynecology and Obstetrics, University of Heidelberg Medical School, 
      Heidelberg, Germany. Michael_Eichbaum@med.uni-heidelberg.de
FAU - de Rossi, Thomas M
AU  - de Rossi TM
FAU - Kaul, Sepp
AU  - Kaul S
FAU - Bruckner, Thomas
AU  - Bruckner T
FAU - Schneeweiss, Andreas
AU  - Schneeweiss A
FAU - Sohn, Christof
AU  - Sohn C
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20061201
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Carcinoembryonic Antigen)
RN  - 0 (Mucin-1)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/blood
MH  - Breast Neoplasms/*blood/*pathology
MH  - Carcinoembryonic Antigen/blood
MH  - Disease Progression
MH  - Female
MH  - Hepatocyte Growth Factor/*blood/physiology
MH  - Humans
MH  - Liver Neoplasms/*blood/*secondary
MH  - Middle Aged
MH  - Mucin-1/blood
MH  - Proto-Oncogene Proteins c-met/physiology
MH  - Signal Transduction/physiology
EDAT- 2006/12/05 09:00
MHDA- 2007/02/14 09:00
CRDT- 2006/12/05 09:00
PHST- 2006/02/10 00:00 [received]
PHST- 2006/05/23 00:00 [accepted]
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2007/02/14 09:00 [medline]
PHST- 2006/12/05 09:00 [entrez]
AID - 97701 [pii]
AID - 10.1159/000097701 [doi]
PST - ppublish
SO  - Tumour Biol. 2007;28(1):36-44. doi: 10.1159/000097701. Epub 2006 Dec 1.