PMID- 17143123
OWN - NLM
STAT- MEDLINE
DCOM- 20070315
LR  - 20220330
IS  - 1741-8267 (Print)
IS  - 1741-8267 (Linking)
VI  - 13
IP  - 6
DP  - 2006 Dec
TI  - VE/VCO2 slope and oxygen uptake efficiency slope in patients with coronary artery 
      disease and intermediate peakVO2.
PG  - 916-23
AB  - BACKGROUND: Peak exercise oxygen uptake (peakVO2) is a widely used 
      prognosticator. Novel spirometric parameters, less affected by submaximal 
      performance, such as the rate of increase of minute ventilation per unit decrease 
      of carbon dioxide production (VE/VCO2 slope) and the oxygen uptake efficiency 
      slope (OUES) have recently been introduced. AIM: To evaluate the discriminative 
      value of OUES, as compared to VE/VCO2 slope in patients with coronary artery 
      disease (CAD) and intermediate peakVO2 values. METHODS AND RESULTS: Bicycle 
      spiroergometry was applied in 214 patients with CAD (age 67+/-8 years, 85% men). 
      OUES was strongly related to peakVO2 (r=0.79). New York Heart Association (NYHA) 
      class, 6-min walking distance, N-terminal pro-brain natriuretic peptide 
      (NT-proBNP), inflammatory markers, left ventricular (LV) volumes and ejection 
      fraction were evaluated. NT-proBNP levels predicted independently VE/VCO2-slope 
      and OUES. Patients with intermediate peakVO2 (12-18 ml/kg per min) and increased 
      VE/VCO2-slope (> or = 35) had higher NYHA class, lower walking distance, higher 
      NT-proBNP levels and higher LV volumes as compared to patients with a similar 
      peakVO2 but lower VE/VCO2-slope. Similar findings were found for patients with 
      intermediate peakVO2 and high OUES/kg (median value>15.3). CONCLUSION: In CAD 
      patients, OUES was strongly correlated with peakVO2. Both VE/VCO2 slope and OUES 
      were independently associated with NT-proBNP levels. Both VE/VCO2 slope and 
      OUES/kg were able to identify a subgroup of patients with an intermediate peakVO2 
      that was characterized by advanced remodelling and a higher degree of 
      neurohumoral activation.
FAU - Van de Veire, Nico R
AU  - Van de Veire NR
AD  - Department of Cardiology, Ghent University, Gent, Belgium. 
      nico.vandeveire@ugent.be
FAU - Van Laethem, Christophe
AU  - Van Laethem C
FAU - Philippe, Jan
AU  - Philippe J
FAU - De Winter, Olivier
AU  - De Winter O
FAU - De Backer, Guy
AU  - De Backer G
FAU - Vanderheyden, Marc
AU  - Vanderheyden M
FAU - De Sutter, Johan
AU  - De Sutter J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Cardiovasc Prev Rehabil
JT  - European journal of cardiovascular prevention and rehabilitation : official 
      journal of the European Society of Cardiology, Working Groups on Epidemiology & 
      Prevention and Cardiac Rehabilitation and Exercise Physiology
JID - 101192000
RN  - 0 (Biomarkers)
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Carbon Dioxide/*metabolism
MH  - Coronary Artery Disease/diagnostic imaging/*metabolism/physiopathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Ergometry
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/*physiology
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 2006/12/05 09:00
MHDA- 2007/03/16 09:00
CRDT- 2006/12/05 09:00
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2007/03/16 09:00 [medline]
PHST- 2006/12/05 09:00 [entrez]
AID - 00149831-200612000-00008 [pii]
AID - 10.1097/01.hjr.0000238400.35094.72 [doi]
PST - ppublish
SO  - Eur J Cardiovasc Prev Rehabil. 2006 Dec;13(6):916-23. doi: 
      10.1097/01.hjr.0000238400.35094.72.