PMID- 17143689
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20070711
LR  - 20220410
IS  - 1439-7595 (Print)
IS  - 1439-7595 (Linking)
VI  - 14
IP  - 3
DP  - 2004
TI  - Increased serum interleukin-18 in a patient with systemic lupus erythematosus and 
      T-cell large granular lymphocytic leukemia.
PG  - 267-70
AB  - Interleukin-18 (IL-18) is a potent cofactor for T-helper (Th-1) cell development 
      and inducer of cytotoxic T lymphocytes (CTL), and is reported to contribute to 
      autoimmune diseases. T-cell large granular lymphocyte (T-LGL) leukemia involves 
      the proliferation of autoreactive CTL that is often associated with autoimmune 
      disorders. We found increased serum IL-18 concentrations in a 55-year-old woman 
      with systemic lupus erythematosus (SLE) and T-LGL-leukemia. Her serum IL-18 
      concentrations correlated with the intensity of her SLE symptoms and the number 
      of T-LGL cells in peripheral blood. This evidence suggests that IL-18 is involved 
      in T-LGL-related autoimmune disorders.
FAU - Ogata, Atsushi
AU  - Ogata A
AD  - Division of Rheumatology, Department of Internal Medicine, Hyogo College of 
      Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8131, Japan. a-ogata@hyo-med.ac.jp
FAU - Kitano, Masayasu
AU  - Kitano M
FAU - Fukamizu, Maki
AU  - Fukamizu M
FAU - Hamano, Teruaki
AU  - Hamano T
FAU - Sano, Hajime
AU  - Sano H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
EDAT- 2006/12/05 09:00
MHDA- 2006/12/05 09:01
CRDT- 2006/12/05 09:00
PHST- 2003/09/29 00:00 [received]
PHST- 2004/03/01 00:00 [accepted]
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2006/12/05 09:01 [medline]
PHST- 2006/12/05 09:00 [entrez]
AID - 10.1007/s10165-004-0306-5 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2004;14(3):267-70. doi: 10.1007/s10165-004-0306-5.