PMID- 17143693
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20070711
LR  - 20161020
IS  - 1439-7595 (Print)
IS  - 1439-7595 (Linking)
VI  - 14
IP  - 5
DP  - 2004
TI  - Cartilage oligomeric matrix protein in serum and synovial fluid of rheumatoid 
      arthritis: potential use as a marker for joint cartilage damage.
PG  - 356-60
AB  - This study examined the serum and synovial fluid concentrations of cartilage 
      oligomeric matrix protein (COMP) in relation to the evolution of joint cartilage 
      damage and the requirement for surgery in 125 patients with rheumatoid arthritis 
      (RA). We compared the erythrocyte sedimentation rate (ESR), C-reactive protein 
      (CRP) level, and matrix metalloproteinase-3 (MMP-3) levels with COMP levels 
      determined by specific enzyme-linked immunosorbent assay (ELISA). Patients were 
      divided into three groups: (1) patients with least erosive disease (LES); (2) 
      patients with more erosive disease (MES); and (3) patients with mutilating 
      disease (MUD). In addition, synovial fluid samples were collected from patients 
      undergoing arthroscopic synovectomy of the knee joint (ASS) and total knee 
      arthroplasty (TKA). Serum COMP levels correlated with the ESR (P < 0.0001, r = 
      0.374, n = 125) and the CRP level (P = 0.0014, r = 0.281, n = 125). COMP levels 
      did not correlate with the MMP-3 level (P = 0.182, r = 0.114, n = 125). The COMP 
      levels of the LES group were significantly lower than those of the MES or MUD 
      groups. Lastly, synovial fluid COMP levels in the TKA group were higher than in 
      the ASS group. Therefore, these findings suggest that serum and synovial fluid 
      COMP levels in patients with RA may reflect cartilage destruction and are 
      correlated with the ESR and the CRP level, which are indicators of the 
      acute-phase response.
FAU - Momohara, Shigeki
AU  - Momohara S
AD  - Department of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's 
      Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan. 
      smomohara@ior.twmu.ac.jp
FAU - Yamanaka, Hisashi
AU  - Yamanaka H
FAU - Holledge, Masumi Maruo
AU  - Holledge MM
FAU - Mizumura, Tamao
AU  - Mizumura T
FAU - Ikari, Katsunori
AU  - Ikari K
FAU - Okada, Naoyuki
AU  - Okada N
FAU - Kamatani, Naoyuki
AU  - Kamatani N
FAU - Tomatsu, Taisuke
AU  - Tomatsu T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
EDAT- 2006/12/05 09:00
MHDA- 2006/12/05 09:01
CRDT- 2006/12/05 09:00
PHST- 2004/01/26 00:00 [received]
PHST- 2004/06/15 00:00 [accepted]
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2006/12/05 09:01 [medline]
PHST- 2006/12/05 09:00 [entrez]
AID - 10.1007/s10165-004-0323-4 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2004;14(5):356-60. doi: 10.1007/s10165-004-0323-4.