PMID- 17143954
OWN - NLM
STAT- MEDLINE
DCOM- 20090611
LR  - 20190430
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 12
IP  - 45
DP  - 2006 Dec 7
TI  - Effects of huoxiangzhengqi liquid on enteric mucosal immune responses in mice 
      with Bacillus dysenteriae and Salmonella typhimurium induced diarrhea.
PG  - 7346-9
AB  - AIM: To explore effects of huoxiangzhengqi liquid (HXZQ) on enteric mucosal 
      immune responses in mice with Bacillus dysenteriae and Salmonella typhimurium 
      induced diarrhea (BSD). METHODS: BSD was induced in Balb/c mice by oral 
      administration with Bacillus dysenteriae and Salmonella typhimurium. HXZQ was 
      administrated from the day of diarrhea induction at dosages of 5.21 g/kg and 0.52 
      g/kg, respectively. The onset of diarrhea and lasting time were recorded. Peyer's 
      patches and peripheral lymphocytes were prepared for flow cytometry, and levels 
      of TNF-alpha in peripheral blood and enteric tissue homogenates were determined 
      with ELISA. Student's t test was employed for statistics. RESULTS: Mice in BSD 
      group started showing continuous diarrhea on the day of induction until the 
      fourth day when they were sacrificed. Diarrhea in the mice of HXZQ high and low 
      dose groups lasted for 36 and 54 h, respectively. There were more CD4+ and CD8+ 
      cells in peripheral blood, fewer CD4+ cells in Peyer's patches in BSD mice 
      compared to normal mice. Fewer CD4+ and CD8+ cells was shown in the mice in HXZQ 
      high group compared to BSD mice. In Peyer's patch, there were more CD8+ cells in 
      mice in HXZQ high and low dose groups and more CD4+ in mice in HXZQ high group. 
      Higher levels of TNF-alpha in peripheral blood and intestinal tissue homogenates 
      in BSD group were observed. Mice in HXZQ high group showed decreased levels of 
      TNF-alpha in peripheral blood and enteric tissue homogenates. CONCLUSION: The 
      immune regulation of CD4+ and CD8+ cells in Peyer's patch and suppression of 
      TNF-alpha levels in enteric homogenates may partially explain the effect of HXZQ 
      on improvement of BSD.
FAU - He, Yin-Hui
AU  - He YH
AD  - National Pharmaceutical Engineering Research Center, Jiangxi University of 
      Traditional Chinese Medicine, Nanchang 33000, Jiangxi Province, China.
FAU - Zhao, Hong-Yan
AU  - Zhao HY
FAU - Liu, Zhen-Li
AU  - Liu ZL
FAU - Lu, Cheng
AU  - Lu C
FAU - Luo, Xiao-Jian
AU  - Luo XJ
FAU - Lin, Se-Qi
AU  - Lin SQ
FAU - Qian, Xing-Wen
AU  - Qian XW
FAU - Chen, Shi-Lin
AU  - Chen SL
FAU - Lu, Ai-Ping
AU  - Lu AP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Huoxiang-zhengqi)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Bacillus/*drug effects
MH  - Bacterial Infections/*drug therapy
MH  - Diarrhea/*drug therapy/microbiology
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Salmonella Infections/*drug therapy
MH  - Salmonella typhimurium/*drug effects
PMC - PMC4087496
EDAT- 2006/12/05 09:00
MHDA- 2009/06/12 09:00
PMCR- 2006/12/07
CRDT- 2006/12/05 09:00
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2009/06/12 09:00 [medline]
PHST- 2006/12/05 09:00 [entrez]
PHST- 2006/12/07 00:00 [pmc-release]
AID - 10.3748/wjg.v12.i45.7346 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2006 Dec 7;12(45):7346-9. doi: 10.3748/wjg.v12.i45.7346.