PMID- 17143972
OWN - NLM
STAT- MEDLINE
DCOM- 20070306
LR  - 20211203
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 34
IP  - 1
DP  - 2007 Jan
TI  - Tumor necrosis factor-alpha promoter -308 A/G polymorphism and rheumatoid 
      arthritis susceptibility: a metaanalysis.
PG  - 43-9
AB  - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) promoter -308 A/G polymorphism 
      has been reported to be associated with rheumatoid arthritis (RA) with 
      inconsistent results. We investigated whether TNF-alpha -308 A/G polymorphism 
      confers susceptibility to RA. METHODS: We conducted a random effect metaanalysis 
      on the association of genotypes A/A (recessive effect), A/A + A/G (dominant 
      effect), A allele, and A/A vs G/G genotypes of the TNF-alpha -308 polymorphisms 
      with RA overall and within different ethnic populations. RESULTS: Fourteen 
      studies, 10 of Europeans, 3 of Latin Americans, and one Asian, were included in 
      this metaanalysis. An association between RA and the TNF-alpha -308 A allele was 
      not found in the overall population (OR 1.005, 95% CI 0.715-1.412, p = 0.976). 
      However, stratification by ethnicity indicated that the TNF-alpha A allele was 
      significantly associated with RA in Latin Americans (OR 2.004, 95% CI 
      1.158-3.467, p = 0.013). Conversely, there was no association detected for the 
      TNF-alpha A allele with RA patients from the European samples (OR 0.911, 95% CI 
      0.684-1.212, p = 0.520). The OR for the A/A + A/G genotype, the A/A genotypes, 
      and the A/A vs G/G genotypes in samples overall and in each ethnic group showed a 
      similar trend to those for the TNF-alpha A allele. CONCLUSION: This metaanalysis 
      demonstrates that the TNF-alpha -308 A/G polymorphism may represent a significant 
      risk factor for RA in Latin Americans, but not in Europeans.
FAU - Lee, Young Ho
AU  - Lee YH
AD  - Division of Rheumatology, Department of Internal Medicine, Korea University 
      Medical Center, College of Medicine, Korea University, Seoul, Korea. 
      lyhcgh@korea.ac.kr
FAU - Ji, Jong Dae
AU  - Ji JD
FAU - Song, Gwan Gyu
AU  - Song GG
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20061115
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alleles
MH  - Arthritis, Rheumatoid/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Hispanic or Latino/ethnology/*genetics
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2006/12/05 09:00
MHDA- 2007/03/07 09:00
CRDT- 2006/12/05 09:00
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2007/03/07 09:00 [medline]
PHST- 2006/12/05 09:00 [entrez]
AID - 06/13/122 [pii]
PST - ppublish
SO  - J Rheumatol. 2007 Jan;34(1):43-9. Epub 2006 Nov 15.