PMID- 17145368
OWN - NLM
STAT- MEDLINE
DCOM- 20070119
LR  - 20171116
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 11
DP  - 2006 Nov
TI  - HBV and HCV infections and acute rejection differentially modulate CD95 and CD28 
      expression on peripheral blood lymphocytes after liver transplantation.
PG  - 884-93
AB  - Hepatitis B virus (HBV) and hepatitis C virus (HCV) generally reinfect liver 
      graft early posttransplantation and lead to poorer graft and patient survivals. 
      In the present study the influence of acute rejection (AR), HBV and HCV 
      infections, and human leukocyte antigen (HLA) class-I compatibility on the 
      expression of CD28 (in 237 liver recipients) and CD95 (in 114 liver recipients) 
      on peripheral blood cells were evaluated by flow cytometry during the first month 
      after transplantation. HBV/HCV infections induced strong CD95 upregulation on 
      CD3+ lymphocytes. Maximal CD95 upmodulation was found in infected recipients 
      showing partial HLA class-I compatibility. AR and virus reinfection could be 
      distinguished because CD28 was upregulated on CD4+ lymphocytes only in recipients 
      with AR, irrespective of their status regarding HBV/HCV infections. In 
      conclusion, cytometric co-evaluation of CD95 and CD28 expression on peripheral 
      blood lymphocytes could be useful to discriminate AR from cellular activation 
      induced by viral reinfection of the liver graft.
FAU - Minguela, Alfredo
AU  - Minguela A
AD  - Immunology Services, Virgen de la Arrixaca University Hospital, Murcia, Spain. 
      alfredo.minguela@carm.es
FAU - Miras, Manuel
AU  - Miras M
FAU - Bermejo, Juan
AU  - Bermejo J
FAU - Sanchez-Bueno, Francisco
AU  - Sanchez-Bueno F
FAU - Lopez-Alvarez, Maria R
AU  - Lopez-Alvarez MR
FAU - Moya-Quiles, Maria R
AU  - Moya-Quiles MR
FAU - Muro, Manuel
AU  - Muro M
FAU - Ontanon, Jesus
AU  - Ontanon J
FAU - Garia-Alonso, Ana M
AU  - Garia-Alonso AM
FAU - Parrilla, Pascual
AU  - Parrilla P
FAU - Alvarez-Lopez, Maria R
AU  - Alvarez-Lopez MR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060728
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Biomarkers)
RN  - 0 (CD28 Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (fas Receptor)
SB  - IM
MH  - Biomarkers/analysis
MH  - CD28 Antigens/*blood
MH  - Flow Cytometry
MH  - Graft Rejection/blood/*immunology
MH  - Hepatitis B/blood/*immunology
MH  - Hepatitis C/blood/*immunology
MH  - Histocompatibility
MH  - Histocompatibility Antigens Class I/immunology/metabolism
MH  - Humans
MH  - Immunocompromised Host
MH  - Leukocytes, Mononuclear/immunology
MH  - Liver Transplantation/*immunology
MH  - Retrospective Studies
MH  - fas Receptor/*blood
EDAT- 2006/12/06 09:00
MHDA- 2007/01/20 09:00
CRDT- 2006/12/06 09:00
PHST- 2005/03/16 00:00 [received]
PHST- 2006/06/20 00:00 [revised]
PHST- 2006/06/29 00:00 [accepted]
PHST- 2006/12/06 09:00 [pubmed]
PHST- 2007/01/20 09:00 [medline]
PHST- 2006/12/06 09:00 [entrez]
AID - S0198-8859(06)00163-7 [pii]
AID - 10.1016/j.humimm.2006.06.005 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Nov;67(11):884-93. doi: 10.1016/j.humimm.2006.06.005. Epub 2006 
      Jul 28.