PMID- 17146563
OWN - NLM
STAT- MEDLINE
DCOM- 20070730
LR  - 20190606
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 39
IP  - 11
DP  - 2006 Nov
TI  - Electrical field stimulation improves bone mineral density in ovariectomized 
      rats.
PG  - 1501-5
AB  - Osteoporosis and its consequent fractures are a great social and medical problem 
      mainly occurring in post-menopausal women. Effective forms of prevention and 
      treatment of osteoporosis associated with lower costs and the least side effects 
      are needed. Electrical fields are able to stimulate osteogenesis in fractures, 
      but little is known about their action on osteoporotic tissue. The aim of the 
      present study was to determine by bone densitometry the effects of electrical 
      stimulation on ovariectomized female Wistar rats. Thirty rats (220 +/- 10 g) were 
      divided into three groups: sham surgery (SHAM), bilateral ovariectomy (OVX) and 
      bilateral ovariectomy + electrical stimulation (OVX + ES). The OVX + ES group was 
      submitted to a 20-min session of a low-intensity pulsed electrical field (1.5 
      MHz, 30 mW/cm(2)) starting on the 7th day after surgery, five times a week (total 
      = 55 sessions). Global, spine and limb bone mineral density were measured by 
      dual-energy X-ray absorptiometry (DXA Hologic 4500A) before surgery and at the 
      end of protocol (84 days after surgery). Electrical stimulation improved (P < 
      0.05) global (0.1522 +/- 0.002), spine (0.1502 +/- 0.003), and limb (0.1294 +/- 
      0.003 g/cm(2)) bone mineral density compared to OVX group (0.1447 +/- 0.001, 
      0.1393 +/- 0.002, and 0.1212 +/- 0.001, respectively). The OVX + ES group also 
      showed significantly higher global bone mineral content (9.547 +/- 0.114 g) when 
      compared to both SHAM (8.693 +/- 0.165 g) and OVX (8.522 +/- 0.207 g) groups (P < 
      0.05). We have demonstrated that electrical fields stimulate osteogenesis in 
      ovariectomized female rats. Their efficacy in osteoporosis remains to be 
      demonstrated.
FAU - Lirani-Galvao, A P R
AU  - Lirani-Galvao AP
AD  - Divisao de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de 
      Sao Paulo, Sao Paulo, SP, Brasil. analirani@fcr.epm.br
FAU - Bergamaschi, C T
AU  - Bergamaschi CT
FAU - Silva, O L
AU  - Silva OL
FAU - Lazaretti-Castro, M
AU  - Lazaretti-Castro M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
SB  - IM
MH  - Absorptiometry, Photon
MH  - Animals
MH  - *Bone Density
MH  - Disease Models, Animal
MH  - *Electric Stimulation Therapy
MH  - Female
MH  - Osteogenesis/*physiology
MH  - Osteoporosis/*therapy
MH  - Ovariectomy
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
EDAT- 2006/12/06 09:00
MHDA- 2007/07/31 09:00
CRDT- 2006/12/06 09:00
PHST- 2005/11/29 00:00 [received]
PHST- 2006/07/21 00:00 [accepted]
PHST- 2006/12/06 09:00 [pubmed]
PHST- 2007/07/31 09:00 [medline]
PHST- 2006/12/06 09:00 [entrez]
AID - S0100-879X2006001100014 [pii]
AID - 10.1590/s0100-879x2006001100014 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2006 Nov;39(11):1501-5. doi: 
      10.1590/s0100-879x2006001100014.