PMID- 17147111
OWN - NLM
STAT- MEDLINE
DCOM- 20080214
LR  - 20131121
IS  - 0253-3766 (Print)
IS  - 0253-3766 (Linking)
VI  - 28
IP  - 7
DP  - 2006 Jul
TI  - [Association between endogenous hormones, hormone receptors and cervical cancer].
PG  - 494-7
AB  - OBJECTIVE: To explore the relationship between the levels of estrogen (E2) and 
      progestogen (P), expression of estrogen receptor (ER) and progesterone receptor 
      (PR) and cervical cancer. METHODS: A case-control study with hospital and 
      community controls was employed. The levels of serum estrogen and progesterone 
      were detected by enzyme linked immunosorbent assay (ELISA) for 141 cervical 
      cancer cases, 137 uterine myoma patients as controls and 129 health women as 
      controls. ER and PR were measured by immunohistochemistry sABC in cervix tissues 
      from patients with cervical cancer and uterus myoma as well. RESULTS: The levels 
      of estrogen (47.49 ng/mL) and progesterone (2.34 pg/mL) in cases were 
      significantly higher than those in both control groups. The association between 
      estrogen and cervical cancer was significant both before and after 
      menopause-adjusted, with over 89% of attributable risk percentage (ARP), and 
      showed a dose-response relation. Using the lowest value of 2 pg/ml in follicular 
      phase as cut off point for progesterone, there were no statistically significant 
      difference between cases and controls, and neither in progesterone nor in 
      premenopausal. The expressions of ER and PR in cases were lower than those in 
      controls, even after being menopause-adjusted. CONCLUSION: The high level of 
      endogenous estrogen and progestogen might increase the risk of cervical cancer. 
      Compared with progestogen, estrogen showed a higher risk that was not influenced 
      by menopause. In some sense, ER and PR may exert certain protective effect on 
      progressing of cervical carcinogenesis.
FAU - Wang, Jin-Tao
AU  - Wang JT
AD  - Department of Epidemiology, Public Health College, Shanxi Medical University, 
      Taiyuan 030001, China.
FAU - Gao, Er-Sheng
AU  - Gao ES
FAU - Ding, Ling
AU  - Ding L
FAU - Cheng, Yu-Ying
AU  - Cheng YY
FAU - Yan, Jian-Wen
AU  - Yan JW
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Zhong Liu Za Zhi
JT  - Zhonghua zhong liu za zhi [Chinese journal of oncology]
JID - 7910681
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Estrogens/*blood
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Leiomyoma/blood/metabolism
MH  - Middle Aged
MH  - Postmenopause/blood/metabolism
MH  - Progesterone/*blood
MH  - Receptors, Estrogen/*analysis
MH  - Receptors, Progesterone/*analysis
MH  - Risk Factors
MH  - Uterine Cervical Neoplasms/*blood/metabolism
MH  - Uterine Neoplasms/blood/metabolism
EDAT- 2006/12/07 09:00
MHDA- 2008/02/15 09:00
CRDT- 2006/12/07 09:00
PHST- 2006/12/07 09:00 [pubmed]
PHST- 2008/02/15 09:00 [medline]
PHST- 2006/12/07 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Zhong Liu Za Zhi. 2006 Jul;28(7):494-7.