PMID- 17148848
OWN - NLM
STAT- MEDLINE
DCOM- 20070313
LR  - 20071115
IS  - 1386-0291 (Print)
IS  - 1386-0291 (Linking)
VI  - 35
IP  - 4
DP  - 2006
TI  - Cardiovascular effects produced by a traditional fungal medicine, Fuscoporia 
      obliqua extract, and microvessels in the left ventricular wall of stroke-prone 
      spontaneously hypertensive rat (SHRSP).
PG  - 491-8
AB  - Studies were carried out on stroke-prone spontaneously hypertensive rats (SHRSP) 
      to determine the cardiovascular effects of a traditional medicine extracted from 
      the fungus Fuscoporia obliqua. The rats received either a hot-water extract of 
      Fuscoporia or tap water for 60 days. Heart rate and blood pressure were measured 
      in the tail and venous blood was analyzed for glycated hemoglobin (HbA1c) and 
      leukocyte number. Sections of the left ventricular wall were stained for alkaline 
      phosphatase and dipeptidylpeptidase IV to distinguish the arteriolar from the 
      venular portions of the capillaries. Capillary to myocyte ratio (C:M ratio) was 
      also measured. Treated rats showed a significant decrease in arterial pressure, a 
      mild increase in leukocyte and a trend towards a decrease in HbA1c. There was a 
      trend towards an increase in total capillary density in the subendomyocardium 
      accompanied by a decrease in the arteriolar capillary portions. C:M ratio showed 
      no clear change. It is concluded that the hot-water extract of Fuscoporia has 
      beneficial effects on cardiovascular function, hematological status and probably 
      immunological function in SHRSP.
FAU - Koyama, Tomiyasu
AU  - Koyama T
AD  - Hokkaido University, Sapporo, Japan. tomkoyamajp@yahoo.co.jp
FAU - Taka, Akira
AU  - Taka A
FAU - Togashi, Hiroko
AU  - Togashi H
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Hemorheol Microcirc
JT  - Clinical hemorheology and microcirculation
JID - 9709206
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Basidiomycota/*chemistry
MH  - Blood Pressure/*drug effects
MH  - Coronary Vessels/*drug effects
MH  - Heart Rate/*drug effects
MH  - Heart Ventricles/*drug effects
MH  - Leukocyte Count
MH  - Microcirculation/drug effects
MH  - Phytotherapy
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Stroke/prevention & control
EDAT- 2006/12/07 09:00
MHDA- 2007/03/14 09:00
CRDT- 2006/12/07 09:00
PHST- 2006/12/07 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2006/12/07 09:00 [entrez]
PST - ppublish
SO  - Clin Hemorheol Microcirc. 2006;35(4):491-8.